Dhx8 MGI Mouse Gene Detail - MGI:1306823

Symbol

Dhx8
Name

DEAH-box helicase 8
Synonyms

Ddx8, mDEAH6, MGC:31290, RNA helicase

Feature Type

protein coding gene
IDs

MGI:1306823
NCBI Gene: 217207
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:101623782-101658184 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.48 cM
Mapping Data

1 experiment

SNPs within 2kb

1029 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1306823	protein coding gene	Chr11:101623745-101658184 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019211	protein coding gene	Chr11:104649795-104689693 (+)
A/J	MGP_AJ_G0019179	protein coding gene	Chr11:100240526-100275962 (+)
AKR/J	MGP_AKRJ_G0019148	protein coding gene	Chr11:103352254-103389297 (+)
BALB/cJ	MGP_BALBcJ_G0019153	protein coding gene	Chr11:100722576-100758224 (+)
C3H/HeJ	MGP_C3HHeJ_G0018962	protein coding gene	Chr11:103537107-103580854 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019602	protein coding gene	Chr11:107921847-107957676 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017228	protein coding gene	Chr11:97661808-97696088 (+)
CAST/EiJ	MGP_CASTEiJ_G0018516	protein coding gene	Chr11:104495562-104530760 (+)
CBA/J	MGP_CBAJ_G0018931	protein coding gene	Chr11:112352456-112393580 (+)
DBA/2J	MGP_DBA2J_G0019043	protein coding gene	Chr11:99761394-99796645 (+)
FVB/NJ	MGP_FVBNJ_G0019033	protein coding gene	Chr11:99289592-99325434 (+)
LP/J	MGP_LPJ_G0019112	protein coding gene	Chr11:105173923-105209450 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019064	protein coding gene	Chr11:111912321-111950264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019640	protein coding gene	Chr11:103691744-103728361 (+)
PWK/PhJ	MGP_PWKPhJ_G0018279	protein coding gene	Chr11:100812835-100848158 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018071	protein coding gene	Chr11:103420898-103464172 (+)
WSB/EiJ	MGP_WSBEiJ_G0018565	protein coding gene	Chr11:103678987-103718224 (+)

Human Ortholog

DHX8, DEAH-box helicase 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DHX8, DEAH-box helicase 8
Synonyms

DDX8, Dhr2, HRH1, PRP22, PRPF22
Links

HGNC:2749

NCBI Gene ID: 1659

neXtProt AC: NX_Q14562

UniProt: Q14562
Chr Location

17q21.31; chr17:43483865-43610338 (+) GRCh38

MGI Vertebrate Homology

Dhx8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DHX8
Gene Tree

Dhx8

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
1 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

2
Gene trapped

12
Targeted

4
Genomic Mutations

1 involving Dhx8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show peri-implantation lethality. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths with a poorly defined inner cell mass after 3 days in culture.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

112

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dhx8

ZFIN dhx8

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All Sequences

52
RefSeq

2
UniProt

7
CCDS

CCDS25479.1

Ensembl

ENSMUSG00000034931 (Evidence)
NCBI Gene

217207

			Length	Strain/Species	Flank
genomic	217207	NCBI Gene Model \| MGI Sequence Detail	34403	C57BL/6J	± kb
transcript	NM_144831	RefSeq \| MGI Sequence Detail	4344	C57BL/6
polypeptide	A2A4P0	UniProt \| EBI \| MGI Sequence Detail	1244	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006473 ATP-dependent RNA helicase DHX8

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR011709 DEAD-box helicase, OB fold

IPR011545 DEAD/DEAH box helicase domain

IPR049588 DHX8, GH2-like domain

IPR049621 DHX8 helicase, S1 domain

IPR044762 DHX8/ Prp22, DEXH-box helicase domain

IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site

IPR007502 Helicase-associated domain

IPR048333 Helicase associated domain (HA2), winged-helix domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR003029 S1 domain

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All nucleic 112

cDNA 112

Microarray probesets 5

Summaries

All 48

Gene Ontology 9

Phenotypes 17
Earliest

J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dhx8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105158	Chr11:101623726-101623729 (+)	-54 bp
Tssr105159	Chr11:101623778-101623791 (+)	3 bp
Tssr105160	Chr11:101623803-101623834 (+)	37 bp
Tssr105161	Chr11:101623837-101623866 (+)	70 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24