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Sema7a Gene Detail
Summary
  • Symbol
    Sema7a
  • Name
    sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
  • Synonyms
    2900057C09Rik, CDw108, Semal, Semaphorin K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306826
    NCBI Gene: 20361
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57847395-57870148 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.63 cM, cytoband A3.3-B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306826
 protein coding gene Chr9:57846879-57870148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034881
 protein coding gene Chr9:57192913-57217365 (+)
A/J MGP_AJ_G0034862
 protein coding gene Chr9:55336797-55359651 (+)
AKR/J MGP_AKRJ_G0034791
 protein coding gene Chr9:56632688-56655426 (+)
BALB/cJ MGP_BALBcJ_G0034854
 protein coding gene Chr9:55115203-55137951 (+)
C3H/HeJ MGP_C3HHeJ_G0034564
 protein coding gene Chr9:57094101-57116919 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035373
 protein coding gene Chr9:58779990-58802730 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032284
 protein coding gene Chr9:54634111-54656967 (+)
CAST/EiJ MGP_CASTEiJ_G0033885
 protein coding gene Chr9:57193807-57216466 (+)
CBA/J MGP_CBAJ_G0034535
 protein coding gene Chr9:60830429-60855560 (+)
DBA/2J MGP_DBA2J_G0034694
 protein coding gene Chr9:55200281-55223397 (+)
FVB/NJ MGP_FVBNJ_G0034636
 protein coding gene Chr9:54441506-54464599 (+)
LP/J MGP_LPJ_G0034777
 protein coding gene Chr9:57486870-57509514 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034679
 protein coding gene Chr9:62322310-62346206 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035395
 protein coding gene Chr9:56639924-56662670 (+)
PWK/PhJ MGP_PWKPhJ_G0033590
 protein coding gene Chr9:55241694-55264645 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033424
 protein coding gene Chr9:56917564-56940146 (+)
WSB/EiJ MGP_WSBEiJ_G0033998
 protein coding gene Chr9:56574512-56600183 (+)



Homology
more
  • Human Ortholog
    SEMA7A, semaphorin 7A (JohnMiltonHagen blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA7A, semaphorin 7A (JohnMiltonHagen blood group)
  • Synonyms
    CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, PFIC11, SEMAK1, SEMAL
  • Links
    NCBI Gene ID: 8482
    neXtProt AC: NX_O75326
    UniProt: O75326

  • Chr Location
    15q24.1; chr15:74409289-74433958 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEMA7A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The development of the olfactory tract is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    159
  • cDNA Data
    20
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038264 Ensembl Gene Model | MGI Sequence Detail 22754 C57BL/6J ±  kb
    transcript ENSMUST00000043059 Ensembl | MGI Sequence Detail 3297 Not Applicable  
    polypeptide ENSMUSP00000042211 Ensembl | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 3
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925657
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 29
      Gene Ontology 8
      Phenotypes 34
    • Earliest
      J:49587 Xu X, et al., Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J Biol Chem. 1998 Aug 28;273(35):22428-34
    • Latest
      J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory