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Marco Gene Detail
Summary
  • Symbol
    Marco
  • Name
    macrophage receptor with collagenous structure
  • Synonyms
    Scara2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309998
    NCBI Gene: 17167
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:120402267-120432753 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.71 cM, cytoband E4-F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    905 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309998
 protein coding gene Chr1:120402267-120432753 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016407
 protein coding gene Chr1:123286956-123317302 (-)
A/J MGP_AJ_G0016390
 protein coding gene Chr1:118860745-118891153 (-)
AKR/J MGP_AKRJ_G0016355
 protein coding gene Chr1:122364206-122396052 (-)
BALB/cJ MGP_BALBcJ_G0016350
 protein coding gene Chr1:119125567-119156733 (-)
C3H/HeJ MGP_C3HHeJ_G0016176
 protein coding gene Chr1:122528237-122560753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016811
 protein coding gene Chr1:127954081-127984413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014524
 protein coding gene Chr1:112499052-112529418 (-)
CAST/EiJ MGP_CASTEiJ_G0015757
 protein coding gene Chr1:121330178-121360517 (-)
CBA/J MGP_CBAJ_G0016149
 protein coding gene Chr1:132418909-132449303 (-)
DBA/2J MGP_DBA2J_G0016255
 protein coding gene Chr1:117882199-117912577 (-)
FVB/NJ MGP_FVBNJ_G0016254
 protein coding gene Chr1:116641112-116671492 (-)
LP/J MGP_LPJ_G0016326
 protein coding gene Chr1:124634608-124667731 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016279
 protein coding gene Chr1:138136690-138168789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016847
 protein coding gene Chr1:122072429-122102773 (-)
PWK/PhJ MGP_PWKPhJ_G0015543
 protein coding gene Chr1:116871134-116901844 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015331
 protein coding gene Chr1:120982469-121014167 (-)
WSB/EiJ MGP_WSBEiJ_G0015819
 protein coding gene Chr1:121962307-121993877 (-)



Homology
more
  • Human Ortholog
    MARCO, macrophage receptor with collagenous structure
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCO, macrophage receptor with collagenous structure
  • Synonyms
    SCARA2, SR-A6
  • Links
    NCBI Gene ID: 8685
    neXtProt AC: NX_Q9UEW3
    UniProt: Q9UEW3

  • Chr Location
    2q14.2; chr2:118942194-118994660 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MARCO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered spleen marginal zone architecture and impaired IgM responses to a pneumococcal polysaccharide vaccine. Mice homozygous for another null allele show increased susceptibility to bacterial pneumonia and enhanced inflammatory responses to inhaled particles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17167 NCBI Gene Model | MGI Sequence Detail 30487 C57BL/6J ±  kb
    transcript NM_010766 RefSeq | MGI Sequence Detail 1963 Not Specified  
    polypeptide Q60754 UniProt | EBI | MGI Sequence Detail 518 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 11
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138205
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 48
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory