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Kcnj15 Gene Detail
Summary
  • Symbol
    Kcnj15
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 15
  • Synonyms
    4930414N08Rik, IRKK, Kir4.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1310000
    NCBI Gene: 16516
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95058417-95101119 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1310000
 protein coding gene Chr16:95058417-95101119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023075
 protein coding gene Chr16:96550304-96594219 (+)
A/J MGP_AJ_G0023043
 protein coding gene Chr16:91990091-92032465 (+)
AKR/J MGP_AKRJ_G0023013
 protein coding gene Chr16:94807270-94849642 (+)
BALB/cJ MGP_BALBcJ_G0023045
 protein coding gene Chr16:92535639-92579037 (+)
C3H/HeJ MGP_C3HHeJ_G0022806
 protein coding gene Chr16:95338631-95383680 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023492
 protein coding gene Chr16:99607244-99649496 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020994
 protein coding gene Chr16:89857673-89902080 (+)
CAST/EiJ MGP_CASTEiJ_G0022325
 protein coding gene Chr16:96114336-96159898 (+)
CBA/J MGP_CBAJ_G0022775
 protein coding gene Chr16:103873257-103929218 (+)
DBA/2J MGP_DBA2J_G0022909
 protein coding gene Chr16:91883481-91926448 (+)
FVB/NJ MGP_FVBNJ_G0022883
 protein coding gene Chr16:91043904-91087179 (+)
LP/J MGP_LPJ_G0022979
 protein coding gene Chr16:96185457-96231360 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022904
 protein coding gene Chr16:108199748-108246633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023510
 protein coding gene Chr16:95345006-95389206 (+)
PWK/PhJ MGP_PWKPhJ_G0022070
 protein coding gene Chr16:92160568-92204467 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021900
 protein coding gene Chr16:94872906-94918095 (+)
WSB/EiJ MGP_WSBEiJ_G0022376
 protein coding gene Chr16:95616654-95658663 (+)



Homology
more
  • Human Ortholog
    KCNJ15, potassium inwardly rectifying channel subfamily J member 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ15, potassium inwardly rectifying channel subfamily J member 15
  • Synonyms
    IRKK, KIR1.3, KIR4.2
  • Links
    NCBI Gene ID: 3772
    neXtProt AC: NX_Q99712
    UniProt: Q99712

  • Chr Location
    21q22.13-q22.2; chr21:38155549-38307357 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice exhibited impaired balance/coordination in a high-throughput screen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1047
  • Tissues
    227
  • cDNA Data
    28
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16516 NCBI Gene Model | MGI Sequence Detail 42703 C57BL/6J ±  kb
transcript NR_073406 RefSeq | MGI Sequence Detail 5455 ZRU/MplStud  
polypeptide O88932 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000001983 ATP-sensitive inward rectifier potassium channel 15
    (term hierarchy)
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR041647 Inward rectifier potassium channel, C-terminal
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003270 Potassium channel, inwardly rectifying, Kir1.3
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
    IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
Molecular
Reagents
less
  • All nucleic 37
    Genomic 2
    cDNA 30
    Primer pair 3
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGI:1921109, MGI:2146383, MGI:2146401
References
more
  • Summaries
    All 140
    Developmental Gene Expression 8
    Diseases 6
    Gene Ontology 7
    Phenotypes 95
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:358265 Zhang Y, et al., Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2. Nat Commun. 2024 Jun 17;15(1):5144
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory