Fmo1 MGI Mouse Gene Detail - MGI:1310002 - flavin containing monooxygenase 1

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Fmo1 Gene Detail

Symbol

Fmo1
Name

flavin containing monooxygenase 1

Feature Type

protein coding gene
IDs

MGI:1310002
NCBI Gene: 14261
Alliance

gene page
Transcription Start Sites

18 TSS
Candidate for QTL

8 QTL

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Sequence Map

Chr1:162657130-162694170 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 70.34 cM, cytoband H1
Mapping Data

3 experiments

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SNPs within 2kb

952 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1310002	protein coding gene	Chr1:162657130-162694179 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016665	protein coding gene	Chr1:168184760-168228422 (-)
A/J	MGP_AJ_G0016646	protein coding gene	Chr1:161341855-161372275 (-)
AKR/J	MGP_AKRJ_G0016612	protein coding gene	Chr1:166218027-166259980 (-)
BALB/cJ	MGP_BALBcJ_G0016607	protein coding gene	Chr1:161850726-161880793 (-)
C3H/HeJ	MGP_C3HHeJ_G0016431	protein coding gene	Chr1:166424090-166457776 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017068	protein coding gene	Chr1:173831893-173869221 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014777	protein coding gene	Chr1:153374625-153407427 (-)
CAST/EiJ	MGP_CASTEiJ_G0016011	protein coding gene	Chr1:166075396-166109792 (-)
CBA/J	MGP_CBAJ_G0016406	protein coding gene	Chr1:180036011-180079235 (-)
DBA/2J	MGP_DBA2J_G0016512	protein coding gene	Chr1:160266903-160297173 (-)
FVB/NJ	MGP_FVBNJ_G0016510	protein coding gene	Chr1:158704401-158735372 (-)
LP/J	MGP_LPJ_G0016583	protein coding gene	Chr1:169293603-169326394 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016535	protein coding gene	Chr1:187542038-187575249 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017104	protein coding gene	Chr1:166050536-166084119 (-)
PWK/PhJ	MGP_PWKPhJ_G0015797	protein coding gene	Chr1:159454130-159484425 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015584	protein coding gene	Chr1:164941607-164975517 (-)
WSB/EiJ	MGP_WSBEiJ_G0016073	protein coding gene	Chr1:166234298-166264136 (-)

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Human Ortholog

FMO1, flavin containing dimethylaniline monoxygenase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FMO1, flavin containing dimethylaniline monoxygenase 1
Links

HGNC:3769

NCBI Gene ID: 2326

neXtProt AC: NX_Q01740

UniProt: Q01740
Chr Location

1q24.3; chr1:171248471-171285978 (+) GRCh38

MGI Vertebrate Homology

Fmo1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FMO1
Protein SuperFamily

FMO
Gene Tree

Fmo1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

3 involving Fmo1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a null mutation display decreased dopaminerginc neuron numbers and increased cytokine levels in the substania nigra.

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All GO Annotations

26
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

18
cDNA Data

115
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fmo1

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All Sequences

62
RefSeq

18
UniProt

5
CCDS

CCDS15424.1, CCDS87907.1

Ensembl

ENSMUSG00000040181 (Evidence)
NCBI Gene

14261

Representative Sequences				Length	Strain/Species	Flank
	genomic	14261	NCBI Gene Model \| MGI Sequence Detail	37041	C57BL/6J	± kb
	transcript	NM_010231	RefSeq \| MGI Sequence Detail	2379	ZRU/MplStud
	polypeptide	P50285	UniProt \| EBI \| MGI Sequence Detail	532	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007574 flavin-containing monooxygenase 1

(term hierarchy)
EC

1.-.-.-, 1.14.13.148, 1.14.13.8
InterPro Domains

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR050346 Flavin-containing Monooxygenases

IPR000960 Flavin monooxygenase FMO

IPR002253 Flavin monooxygenase (FMO) 1

IPR020946 Flavin monooxygenase-like
GlyGen

P50285 1 site, 1 O-linked glycan (1 site)

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All nucleic 116

cDNA 116

Microarray probesets 3

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Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 11
Earliest

J:28615 Falls JG, et al., Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. J Biochem Toxicol. 1995 Jun;10(3):171-7
Latest

J:312983 Li B, et al., Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice. Neurosci Lett. 2021 Nov 1;764:136222

TSS for Fmo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14678	Chr1:162694071-162694185 (-)	42 bp
Tssr14677	Chr1:162694052-162694070 (-)	109 bp
Tssr14676	Chr1:162694032-162694037 (-)	135 bp
Tssr14675	Chr1:162694009-162694020 (-)	155 bp
Tssr14674	Chr1:162693994-162694001 (-)	172 bp
Tssr14673	Chr1:162693928-162693971 (-)	220 bp
Tssr14672	Chr1:162687683-162687695 (-)	6,481 bp
Tssr14671	Chr1:162687666-162687677 (-)	6,498 bp
Tssr14670	Chr1:162687648-162687663 (-)	6,514 bp
Tssr14669	Chr1:162687629-162687646 (-)	6,532 bp
Tssr14668	Chr1:162687553-162687563 (-)	6,612 bp
Tssr14667	Chr1:162687488-162687542 (-)	6,655 bp
Tssr14666	Chr1:162687441-162687452 (-)	6,723 bp
Tssr14665	Chr1:162687400-162687411 (-)	6,764 bp
Tssr14664	Chr1:162687380-162687394 (-)	6,783 bp
Tssr14663	Chr1:162687253-162687304 (-)	6,891 bp
Tssr14662	Chr1:162687125-162687141 (-)	7,037 bp
Tssr14661	Chr1:162661872-162661876 (-)	32,296 bp

Fmo1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Insq2	Chr1, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Insq6	Chr1, 38.01 cM	Chr1:73726922-73727077	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Nidd6	Chr1, 65.11 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Obq2	Chr1, 6.50 cM	Chr1:20941620-20941887	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Obq7	Chr1, 33.31 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Obq9	Chr1, 74.68 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Wt6q1	Chr1, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Wt6q2	Chr1, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.

*cM position of peak correlated region/marker

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