Fmo5 MGI Mouse Gene Detail - MGI:1310004 - flavin containing monooxygenase 5

Symbol

Fmo5
Name

flavin containing monooxygenase 5
Synonyms

5033418D19Rik

Feature Type

protein coding gene
IDs

MGI:1310004
NCBI Gene: 14263
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:97536120-97562598 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 42.23 cM
Mapping Data

3 experiments

SNPs within 2kb

814 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1310004	protein coding gene	Chr3:97517248-97562603 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027642	protein coding gene	Chr3:98583030-98609324 (+)
A/J	MGP_AJ_G0027604	protein coding gene	Chr3:95427976-95454455 (+)
AKR/J	MGP_AKRJ_G0027571	protein coding gene	Chr3:97710988-97739259 (+)
BALB/cJ	MGP_BALBcJ_G0027614	protein coding gene	Chr3:95211524-95252988 (+)
C3H/HeJ	MGP_C3HHeJ_G0027346	protein coding gene	Chr3:97981143-98008400 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028060	protein coding gene	Chr3:102248445-102277584 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025402	protein coding gene	Chr3:91688245-91714759 (+)
CAST/EiJ	MGP_CASTEiJ_G0026801	protein coding gene	Chr3:97272339-97302055 (+)
CBA/J	MGP_CBAJ_G0027321	protein coding gene	Chr3:105892647-105921164 (+)
DBA/2J	MGP_DBA2J_G0027464	protein coding gene	Chr3:94742161-94768580 (+)
FVB/NJ	MGP_FVBNJ_G0027433	protein coding gene	Chr3:92731872-92758692 (+)
LP/J	MGP_LPJ_G0027569	protein coding gene	Chr3:99841248-99868661 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027459	protein coding gene	Chr3:111982995-112015558 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028114	protein coding gene	Chr3:97337706-97364177 (+)
PWK/PhJ	MGP_PWKPhJ_G0026526	protein coding gene	Chr3:94606952-94634604 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026348	protein coding gene	Chr3:95611994-95637557 (+)
WSB/EiJ	MGP_WSBEiJ_G0026879	protein coding gene	Chr3:97770299-97796836 (+)

Human Ortholog

FMO5, flavin containing dimethylaniline monoxygenase 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FMO5, flavin containing dimethylaniline monoxygenase 5
Synonyms

hBVMO1
Links

HGNC:3773

NCBI Gene ID: 2330

neXtProt AC: NX_P49326

UniProt: P49326
Chr Location

1q21.1; chr1:147175351-147243050 (-) GRCh38

MGI Vertebrate Homology

Fmo5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FMO5
Protein SuperFamily

FMO
Gene Tree

Fmo5

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References

1 with disease annotations

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Phenotype Summary

32 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Fmo5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show an age-related lean phenotype despite increased food intake, lower plasma levels of glucose and cholesterol, decreased fat storage in WAT, altered fatty acid oxidation, increased energy expenditure and respiratory quotient but normal physical activity.

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All GO Annotations

22
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

96
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fmo5.2

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All Sequences

64
RefSeq

20
UniProt

3
CCDS

CCDS17656.1

Ensembl

ENSMUSG00000028088 (Evidence)
NCBI Gene

14263

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028088	Ensembl Gene Model \| MGI Sequence Detail	26479	C57BL/6J	± kb
transcript	ENSMUST00000107050	Ensembl \| MGI Sequence Detail	5197	Not Applicable
polypeptide	ENSMUSP00000102665	Ensembl \| MGI Sequence Detail	533	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007578 flavin-containing monooxygenase 5

(term hierarchy)
EC

1.14.13.8, 1.6.3.1
InterPro Domains

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR050346 Flavin-containing Monooxygenases

IPR000960 Flavin monooxygenase FMO

IPR002257 Flavin monooxygenase (FMO) 5

IPR020946 Flavin monooxygenase-like
GlyGen

P97872 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 6

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MGI:1923220, MGI:2139645

Summaries

All 53

Developmental Gene Expression 2

Diseases 1

Gene Ontology 11

Phenotypes 16
Earliest

J:28615 Falls JG, et al., Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. J Biochem Toxicol. 1995 Jun;10(3):171-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fmo5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30791	Chr3:97536160-97536180 (+)	50 bp
Tssr30792	Chr3:97540474-97540485 (+)	4,360 bp
Tssr30793	Chr3:97558990-97559010 (+)	22,880 bp
Tssr30794	Chr3:97559067-97559081 (+)	22,954 bp
Tssr30795	Chr3:97559101-97559113 (+)	22,987 bp
Tssr30796	Chr3:97559138-97559146 (+)	23,022 bp
Tssr30797	Chr3:97559169-97559181 (+)	23,055 bp
Tssr974	Chr3:97559205-97559236 (+)	23,101 bp
Tssr30798	Chr3:97559288-97559362 (+)	23,205 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24