Casp6 MGI Mouse Gene Detail - MGI:1312921

Symbol

Casp6
Name

caspase 6
Synonyms

mCASP-6, Mch2

Feature Type

protein coding gene
IDs

MGI:1312921
NCBI Gene: 12368
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:129695074-129707752 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 59.50 cM, cytoband H1
Mapping Data

2 experiments

SNPs within 2kb

642 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1312921	protein coding gene	Chr3:129695064-129707761 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027877	protein coding gene	Chr3:132592884-132607088 (+)
A/J	MGP_AJ_G0027835	protein coding gene	Chr3:127972329-127984966 (+)
AKR/J	MGP_AKRJ_G0027800	protein coding gene	Chr3:131289716-131302269 (+)
BALB/cJ	MGP_BALBcJ_G0027848	protein coding gene	Chr3:127815184-127828105 (+)
C3H/HeJ	MGP_C3HHeJ_G0027577	protein coding gene	Chr3:131683725-131696985 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028292	protein coding gene	Chr3:137330763-137344258 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025630	protein coding gene	Chr3:123499358-123513988 (+)
CAST/EiJ	MGP_CASTEiJ_G0027034	protein coding gene	Chr3:131364407-131376914 (+)
CBA/J	MGP_CBAJ_G0027553	protein coding gene	Chr3:141944943-141960275 (+)
DBA/2J	MGP_DBA2J_G0027694	protein coding gene	Chr3:127165353-127177991 (+)
FVB/NJ	MGP_FVBNJ_G0027661	protein coding gene	Chr3:124756880-124769391 (+)
LP/J	MGP_LPJ_G0027803	protein coding gene	Chr3:134100042-134112613 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027692	protein coding gene	Chr3:149906847-149920258 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028349	protein coding gene	Chr3:130963562-130976031 (+)
PWK/PhJ	MGP_PWKPhJ_G0026758	protein coding gene	Chr3:126906339-126919426 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026583	protein coding gene	Chr3:129024137-129042824 (+)
WSB/EiJ	MGP_WSBEiJ_G0027113	protein coding gene	Chr3:131676051-131690004 (+)

Human Ortholog

CASP6, caspase 6

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP6, caspase 6
Synonyms

caspase-6, CSP-6, MCH2
Links

HGNC:1507

NCBI Gene ID: 839

neXtProt AC: NX_P55212

UniProt: P55212
Chr Location

4q25; chr4:109664388-109709767 (-) GRCh38

MGI Vertebrate Homology

Casp6 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CASP6
Gene Tree

Casp6

Diseases

1 with human CASP6 associations

				Human Disease	Mouse Models
				ovarian carcinoma IDs ovarian carcinoma DOID:4001 EFO:0001075 UMLS_CUI:C0677886

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

3 involving Casp6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit failure to induce increased lysis of fluorogenic substrate VEID-AMC in staurosporine treated of lenses. Mice homozygous for a different knock-out allele exhibit resistance to excitotoxicity and axonal degeneration.

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All GO Annotations

52
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

930
Tissues

67
cDNA Data

78
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase casp6

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All Sequences

45
RefSeq

2
UniProt

4
CCDS

CCDS17838.1

Ensembl

ENSMUSG00000027997 (Evidence)
NCBI Gene

12368

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027997	Ensembl Gene Model \| MGI Sequence Detail	12679	C57BL/6J	± kb
transcript	ENSMUST00000029626	Ensembl \| MGI Sequence Detail	1456	Not Applicable
polypeptide	ENSMUSP00000029626	Ensembl \| MGI Sequence Detail	276	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000002315 caspase-6

(term hierarchy)
EC

3.4.22.59
InterPro Domains

IPR029030 Caspase-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

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All nucleic 83

Genomic 1

cDNA 78

Primer pair 3

Other 1

Microarray probesets 3

Summaries

All 88

Developmental Gene Expression 13

Diseases 1

Gene Ontology 8

Phenotypes 32
Earliest

J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
Latest

J:344262 Lin Y, et al., Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IkappaBalpha axis in liver inflammation. Cell Commun Signal. 2023 Oct 12;21(1):282

TSS for Casp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31661	Chr3:129695068-129695079 (+)	0 bp
Tssr31662	Chr3:129695080-129695115 (+)	24 bp
Tssr31663	Chr3:129695117-129695139 (+)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24