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Alcam Gene Detail
Summary
  • Symbol
    Alcam
  • Name
    activated leukocyte cell adhesion molecule
  • Synonyms
    BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313266
    NCBI Gene: 11658
  • Alliance
    gene page
  • Transcription Start Sites
    70 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:52069359-52273444 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 32.88 cM, cytoband B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5857 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313266
 protein coding gene Chr16:52069359-52274437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022878
 protein coding gene Chr16:51197198-51406973 (-)
A/J MGP_AJ_G0022845
 protein coding gene Chr16:48968739-49180685 (-)
AKR/J MGP_AKRJ_G0022817
 protein coding gene Chr16:50606532-50810942 (-)
BALB/cJ MGP_BALBcJ_G0022845
 protein coding gene Chr16:49066879-49269819 (-)
C3H/HeJ MGP_C3HHeJ_G0022608
 protein coding gene Chr16:50693682-50905847 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023293
 protein coding gene Chr16:52566776-52776435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020805
 protein coding gene Chr16:48928877-49130546 (-)
CAST/EiJ MGP_CASTEiJ_G0022134
 protein coding gene Chr16:51063003-51277134 (-)
CBA/J MGP_CBAJ_G0022581
 protein coding gene Chr16:54655513-54873249 (-)
DBA/2J MGP_DBA2J_G0022713
 protein coding gene Chr16:48717885-48915447 (-)
FVB/NJ MGP_FVBNJ_G0022688
 protein coding gene Chr16:48555937-48756189 (-)
LP/J MGP_LPJ_G0022780
 protein coding gene Chr16:50996729-51211475 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022706
 protein coding gene Chr16:54438380-54679080 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023308
 protein coding gene Chr16:50685724-50897003 (-)
PWK/PhJ MGP_PWKPhJ_G0021874
 protein coding gene Chr16:49042713-49244112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021704
 protein coding gene Chr16:50500128-50707384 (-)
WSB/EiJ MGP_WSBEiJ_G0022179
 protein coding gene Chr16:50656247-50865331 (-)



Homology
more
  • Human Ortholog
    ALCAM, activated leukocyte cell adhesion molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALCAM, activated leukocyte cell adhesion molecule
  • Synonyms
    CD166, MEMD
  • Links
    NCBI Gene ID: 214
    neXtProt AC: NX_Q13740
    UniProt: Q13740

  • Chr Location
    3q13.11; chr3:105366909-105576900 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal motor neuron and retinal ganglion cell morphology and retinal dysplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1168
  • Tissues
    181
  • cDNA Data
    14
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11658 NCBI Gene Model | MGI Sequence Detail 204086 C57BL/6J ±  kb
    transcript NM_009655 RefSeq | MGI Sequence Detail 5063 C57BL/6  
    polypeptide Q61490 UniProt | EBI | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 15
      Primer pair 5
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2146511
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 65
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:19352 Kanki JP, et al., The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. J Neurobiol. 1994 Jul;25(7):831-45
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory