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Eif2b3 Gene Detail
Summary
  • Symbol
    Eif2b3
  • Name
    eukaryotic translation initiation factor 2B, subunit 3
  • Synonyms
    1190002P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313286
    NCBI Gene: 108067
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116876559-116944049 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1569 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313286
 protein coding gene Chr4:116876559-116944503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028641
 protein coding gene Chr4:117969418-118043197 (+)
A/J MGP_AJ_G0028602
 protein coding gene Chr4:113423261-113492299 (+)
AKR/J MGP_AKRJ_G0028552
 protein coding gene Chr4:115901298-115970584 (+)
BALB/cJ MGP_BALBcJ_G0028623
 protein coding gene Chr4:114054283-114123357 (+)
C3H/HeJ MGP_C3HHeJ_G0028337
 protein coding gene Chr4:117464066-117533887 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029064
 protein coding gene Chr4:122519310-122594323 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026348
 protein coding gene Chr4:107466970-107537945 (+)
CAST/EiJ MGP_CASTEiJ_G0027771
 protein coding gene Chr4:114684815-114748163 (+)
CBA/J MGP_CBAJ_G0028304
 protein coding gene Chr4:125864684-125940912 (+)
DBA/2J MGP_DBA2J_G0028452
 protein coding gene Chr4:114059028-114127288 (+)
FVB/NJ MGP_FVBNJ_G0028420
 protein coding gene Chr4:112562100-112631736 (+)
LP/J MGP_LPJ_G0028554
 protein coding gene Chr4:118150290-118220782 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028447
 protein coding gene Chr4:130816403-130891978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029101
 protein coding gene Chr4:117049014-117119668 (+)
PWK/PhJ MGP_PWKPhJ_G0027497
 protein coding gene Chr4:110846003-110920901 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027320
 protein coding gene Chr4:113339209-113409613 (+)
WSB/EiJ MGP_WSBEiJ_G0027850
 protein coding gene Chr4:116915584-116985478 (+)



Homology
more
  • Human Ortholog
    EIF2B3, eukaryotic translation initiation factor 2B subunit gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2B3, eukaryotic translation initiation factor 2B subunit gamma
  • Synonyms
    EIF-2B, EIF2Bgamma, VWM3
  • Links
    NCBI Gene ID: 8891
    neXtProt AC: NX_Q9NR50
    UniProt: Q9NR50

  • Chr Location
    1p34.1; chr1:44850522-44986722 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF2B3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    31
  • cDNA Data
    52
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108067 NCBI Gene Model | MGI Sequence Detail 67491 C57BL/6J ±  kb
    transcript NM_175135 RefSeq | MGI Sequence Detail 3760 C57BL/6  
    polypeptide NP_001104747 RefSeq | MGI Sequence Detail 452 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR051960 Eukaryotic Initiation Factor 2B Subunit Gamma
      IPR029044 Nucleotide-diphospho-sugar transferases
      IPR005835 Nucleotidyl transferase domain
      IPR011004 Trimeric LpxA-like superfamily
    • GlyGen
      B1AUN2 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1916112
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory