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Incenp Gene Detail
Summary
  • Symbol
    Incenp
  • Name
    inner centromere protein
  • Synonyms
    2700067E22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313288
    NCBI Gene: 16319
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:9849659-9876853 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    571 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313288
 protein coding gene Chr19:9849659-9876915 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024832
 protein coding gene Chr19:7172201-7202182 (-)
A/J MGP_AJ_G0024800
 protein coding gene Chr19:6656765-6686106 (-)
AKR/J MGP_AKRJ_G0024775
 protein coding gene Chr19:6938931-6970768 (-)
BALB/cJ MGP_BALBcJ_G0024800
 protein coding gene Chr19:6718788-6745943 (-)
C3H/HeJ MGP_C3HHeJ_G0024566
 protein coding gene Chr19:6823769-6851169 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025248
 protein coding gene Chr19:7464359-7491269 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022675
 protein coding gene Chr19:7093842-7121336 (-)
CAST/EiJ MGP_CASTEiJ_G0024039
 protein coding gene Chr19:6471393-6499537 (-)
CBA/J MGP_CBAJ_G0024540
 protein coding gene Chr19:7559184-7590352 (-)
DBA/2J MGP_DBA2J_G0024667
 protein coding gene Chr19:6689396-6717336 (-)
FVB/NJ MGP_FVBNJ_G0024634
 protein coding gene Chr19:6721915-6749791 (-)
LP/J MGP_LPJ_G0024754
 protein coding gene Chr19:7148912-7178710 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024661
 protein coding gene Chr19:7463038-7491361 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025296
 protein coding gene Chr19:6964661-6993135 (-)
PWK/PhJ MGP_PWKPhJ_G0023784
 protein coding gene Chr19:6118865-6146980 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023589
 protein coding gene Chr19:6130847-6179978 (-)
WSB/EiJ MGP_WSBEiJ_G0024101
 protein coding gene Chr19:6846867-6875840 (-)



Homology
more
  • Human Ortholog
    INCENP, inner centromere protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INCENP, inner centromere protein
  • Links
    NCBI Gene ID: 3619
    neXtProt AC: NX_Q9NQS7
    UniProt: Q9NQS7

  • Chr Location
    11q12.3; chr11:62123998-62155474 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant embryos die before E8.5. Embryonic cells exhibit abnormal nuclei and abberent mitosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    6
  • cDNA Data
    15
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16319 NCBI Gene Model | MGI Sequence Detail 27195 C57BL/6J ±  kb
    transcript NM_001369356 RefSeq | MGI Sequence Detail 3187 ZRU/MplStud  
    polypeptide Q9WU62 UniProt | EBI | MGI Sequence Detail 880 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009029 inner centromere protein
      (term hierarchy)
    • InterPro Domains
      IPR022006 Chromosome passenger complex (CPC) protein INCENP N-terminal
      IPR005635 Inner centromere protein, ARK-binding domain
    • GlyGen
      Q9WU62 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 17
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919833, MGI:2147646, MGI:2147779
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:50321 Fowler KJ, et al., Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Cytogenet Cell Genet. 1998;82(1-2):67-70
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory