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Cenpf Gene Detail
Summary
  • Symbol
    Cenpf
  • Name
    centromere protein F
  • Synonyms
    6530404A22Rik, Lek1, mitosin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313302
    NCBI Gene: 108000
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:189372803-189420283 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 95.03 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313302
 protein coding gene Chr1:189372803-189420302 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016928
 protein coding gene Chr1:196552591-196601183 (-)
A/J MGP_AJ_G0016907
 protein coding gene Chr1:188513701-188561137 (-)
AKR/J MGP_AKRJ_G0016872
 protein coding gene Chr1:194064752-194114499 (-)
BALB/cJ MGP_BALBcJ_G0016865
 protein coding gene Chr1:189189520-189236916 (-)
C3H/HeJ MGP_C3HHeJ_G0016689
 protein coding gene Chr1:194935778-194984090 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017328
 protein coding gene Chr1:202832197-202881525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015035
 protein coding gene Chr1:179442674-179490052 (-)
CAST/EiJ MGP_CASTEiJ_G0016272
 protein coding gene Chr1:194502854-194556726 (-)
CBA/J MGP_CBAJ_G0016663
 protein coding gene Chr1:210392098-210441426 (-)
DBA/2J MGP_DBA2J_G0016769
 protein coding gene Chr1:187255250-187303131 (-)
FVB/NJ MGP_FVBNJ_G0016765
 protein coding gene Chr1:185366139-185414254 (-)
LP/J MGP_LPJ_G0016844
 protein coding gene Chr1:197732474-197782503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016797
 protein coding gene Chr1:217115407-217168406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017365
 protein coding gene Chr1:193983634-194030938 (-)
PWK/PhJ MGP_PWKPhJ_G0016059
 protein coding gene Chr1:186513088-186561125 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015835
 protein coding gene Chr1:192949539-193005019 (-)
WSB/EiJ MGP_WSBEiJ_G0016334
 protein coding gene Chr1:194180629-194228880 (-)



Homology
more
  • Human Ortholog
    CENPF, centromere protein F
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPF, centromere protein F
  • Synonyms
    CENF, CILD31, hcp-1, PRO1779, STROMS
  • Links
    NCBI Gene ID: 1063
    neXtProt AC: NX_P49454
    UniProt: P49454

  • Chr Location
    1q41; chr1:214603185-214664574 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cenpf mouse models; 1 with human CENPF associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Surprisingly, mice homozygous for any of three endonuclease-mediated mutations that specifically disrupt different domains of CENPF important for mitosis and mitochondrial regulation are viable, fertile and reach adulthood without any apparent phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    120
  • cDNA Data
    147
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026605 Ensembl Gene Model | MGI Sequence Detail 47481 C57BL/6J ±  kb
    transcript ENSMUST00000171929 Ensembl | MGI Sequence Detail 11130 Not Applicable  
    polypeptide ENSMUSP00000129738 Ensembl | MGI Sequence Detail 2997 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR043513 Centromere protein Cenp-F
      IPR019513 Centromere protein Cenp-F, leucine-rich repeat-containing domain
      IPR018463 Centromere protein Cenp-F, N-terminal
      IPR018302 Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain
    Molecular
    Reagents
    less
    • All nucleic 150
      Genomic 1
      cDNA 147
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1344369, MGI:1915046, MGI:2138210
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:124762 Zhu X, et al., Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. Mol Cell Biol. 1995 Sep;15(9):5017-29
    • Latest
      J:350493 Sun B, et al., Ezh2-dependent methylation in oral epithelia promotes secondary palatogenesis. Birth Defects Res. 2023 Nov 15;115(19):1851-1865
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory