Khdrbs3 MGI Mouse Gene Detail - MGI:1313312 - KH domain containing, RNA binding, signal transduction associated 3

Symbol

Khdrbs3
Name

KH domain containing, RNA binding, signal transduction associated 3
Synonyms

Etle, Salp, SLM-2, T-STAR

Feature Type

protein coding gene
IDs

MGI:1313312
NCBI Gene: 13992
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:68800269-68973060 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 30.36 cM
Mapping Data

3 experiments

SNPs within 2kb

5397 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1313312	protein coding gene	Chr15:68800155-68973064 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021913	protein coding gene	Chr15:68503769-68684662 (+)
A/J	MGP_AJ_G0021872	protein coding gene	Chr15:65929371-66088815 (+)
AKR/J	MGP_AKRJ_G0021854	protein coding gene	Chr15:67736728-67904709 (+)
BALB/cJ	MGP_BALBcJ_G0021879	protein coding gene	Chr15:66092354-66252842 (+)
C3H/HeJ	MGP_C3HHeJ_G0021652	protein coding gene	Chr15:67850504-68007130 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022318	protein coding gene	Chr15:71097691-71275752 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019855	protein coding gene	Chr15:62645692-62796873 (+)
CAST/EiJ	MGP_CASTEiJ_G0021171	protein coding gene	Chr15:68553556-68714794 (+)
CBA/J	MGP_CBAJ_G0021618	protein coding gene	Chr15:73473824-73648637 (+)
DBA/2J	MGP_DBA2J_G0021743	protein coding gene	Chr15:65688790-65850898 (+)
FVB/NJ	MGP_FVBNJ_G0021725	protein coding gene	Chr15:64708209-64869662 (+)
LP/J	MGP_LPJ_G0021815	protein coding gene	Chr15:68438934-68614856 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021748	protein coding gene	Chr15:78601382-78770836 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022340	protein coding gene	Chr15:68136429-68296075 (+)
PWK/PhJ	MGP_PWKPhJ_G0020912	protein coding gene	Chr15:65771543-65932853 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020753	protein coding gene	Chr15:67968015-68141880 (+)
WSB/EiJ	MGP_WSBEiJ_G0021223	protein coding gene	Chr15:68095141-68260876 (+)

Human Ortholog

KHDRBS3, KH RNA binding domain containing, signal transduction associated 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KHDRBS3, KH RNA binding domain containing, signal transduction associated 3
Synonyms

Etle, etoile, SALP, SLM-2, SLM2, T-STAR, TSTAR
Links

HGNC:18117

NCBI Gene ID: 10656

neXtProt AC: NX_O75525

UniProt: O75525
Chr Location

8q24.23; chr8:135457456-135656722 (+) GRCh38

MGI Vertebrate Homology

Khdrbs3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KHDRBS3
Gene Tree

Khdrbs3

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

2
Targeted

8
Genomic Mutations

5 involving Khdrbs3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and fertile with no detectable spatial memory deficits. Males sire slightly smaller litters than control males.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

53
cDNA Data

25
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase khdrbs3

ZFIN khdrbs3

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All Sequences

50
RefSeq

8
UniProt

3
CCDS

CCDS27513.1

Ensembl

ENSMUSG00000022332 (Evidence)
NCBI Gene

13992

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022332	Ensembl Gene Model \| MGI Sequence Detail	172792	C57BL/6J	± kb
transcript	ENSMUST00000229234	Ensembl \| MGI Sequence Detail	2861	Not Applicable
polypeptide	ENSMUSP00000154887	Ensembl \| MGI Sequence Detail	346	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009281 KH domain-containing, RNA-binding, signal transduction-associated protein 3

(term hierarchy)
InterPro Domains

IPR045071 KH domain-containing BBP-like

IPR032571 KHDRBS, Qua1 domain

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

IPR032335 Sam68, tyrosine-rich domain
GlyGen

Q9R226 1 site, 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 26

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 81

Developmental Gene Expression 8

Diseases 1

Gene Ontology 8

Phenotypes 42
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353360 Cesari E, et al., Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184

TSS for Khdrbs3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131505	Chr15:68800229-68800242 (+)	-33 bp
Tssr131506	Chr15:68800244-68800258 (+)	-18 bp
Tssr131507	Chr15:68800263-68800270 (+)	-2 bp
Tssr131508	Chr15:68800272-68800301 (+)	18 bp
Tssr131509	Chr15:68800311-68800332 (+)	53 bp
Tssr131510	Chr15:68800552-68800578 (+)	296 bp
Tssr131511	Chr15:68801208-68801225 (+)	948 bp
Tssr131512	Chr15:68912856-68912859 (+)	112,589 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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