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Cldn4 Gene Detail
Summary
  • Symbol
    Cldn4
  • Name
    claudin 4
  • Synonyms
    Cpetr, Cpetr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313314
    NCBI Gene: 12740
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134973977-134975788 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.90 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313314
 protein coding gene Chr5:134973973-134975788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030167
 protein coding gene Chr5:139414126-139417066 (-)
A/J MGP_AJ_G0030135
 protein coding gene Chr5:133467390-133469213 (-)
AKR/J MGP_AKRJ_G0030068
 protein coding gene Chr5:137808303-137809966 (-)
BALB/cJ MGP_BALBcJ_G0030145
 protein coding gene Chr5:134823273-134824924 (-)
C3H/HeJ MGP_C3HHeJ_G0029861
 protein coding gene Chr5:138365816-138367623 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030598
 protein coding gene Chr5:144648248-144652379 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027821
 protein coding gene Chr5:127763545-127765205 (-)
CAST/EiJ MGP_CASTEiJ_G0029270
 protein coding gene Chr5:137789692-137791499 (-)
CBA/J MGP_CBAJ_G0029831
 protein coding gene Chr5:150298398-150300219 (-)
DBA/2J MGP_DBA2J_G0029982
 protein coding gene Chr5:133364036-133365860 (-)
FVB/NJ MGP_FVBNJ_G0029937
 protein coding gene Chr5:132496483-132498288 (-)
LP/J MGP_LPJ_G0030070
 protein coding gene Chr5:139874396-139876214 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029969
 protein coding gene Chr5:153320582-153322391 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030638
 protein coding gene Chr5:137543326-137545147 (-)
PWK/PhJ MGP_PWKPhJ_G0028985
 protein coding gene Chr5:132408076-132409878 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028820
 protein coding gene Chr5:135113612-135115421 (-)
WSB/EiJ MGP_WSBEiJ_G0029344
 protein coding gene Chr5:138298233-138300044 (-)



Homology
more
  • Human Ortholog
    CLDN4, claudin 4
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN4, claudin 4
  • Synonyms
    CPE-R, CPER, CPETR, CPETR1, hCPE-R, WBSCR8
  • Links
    NCBI Gene ID: 1364
    neXtProt AC: NX_O14493
    UniProt: O14493

  • Chr Location
    7q11.23; chr7:73799542-73832690 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CLDN4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hydropherosis due to kidney pelvis and ureteral urothelium proliferation that leads to impaired calcium and chloride ion reabsorbtion and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    84
  • cDNA Data
    102
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12740 NCBI Gene Model | MGI Sequence Detail 1812 C57BL/6J ±  kb
    transcript NM_009903 RefSeq | MGI Sequence Detail 1827 ZRU/MplStud  
    polypeptide O35054 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      Genomic 4
      cDNA 102
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1202393
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 16
      Phenotypes 17
    • Earliest
      J:43620 Katahira J, et al., Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997 Oct 17;272(42):26652-8
    • Latest
      J:345312 Mak S, et al., Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory