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Aqp7 Gene Detail
Summary
  • Symbol
    Aqp7
  • Name
    aquaporin 7
  • Synonyms
    AQP7L, AQPap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314647
    NCBI Gene: 11832
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41033074-41048139 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.83 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    491 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314647
 protein coding gene Chr4:41033074-41048237 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028153
 protein coding gene Chr4:38952863-38968408 (-)
A/J MGP_AJ_G0028111
 protein coding gene Chr4:37476842-37492563 (-)
AKR/J MGP_AKRJ_G0028074
 protein coding gene Chr4:38434379-38449825 (-)
BALB/cJ MGP_BALBcJ_G0028123
 protein coding gene Chr4:37808884-37823800 (-)
C3H/HeJ MGP_C3HHeJ_G0027851
 protein coding gene Chr4:38975724-38992210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028564
 protein coding gene Chr4:40385248-40405727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025905
 protein coding gene Chr4:35129551-35144221 (-)
CAST/EiJ MGP_CASTEiJ_G0027307
 protein coding gene Chr4:38630676-38647999 (-)
CBA/J MGP_CBAJ_G0027823
 protein coding gene Chr4:41755607-41780490 (-)
DBA/2J MGP_DBA2J_G0027967
 protein coding gene Chr4:37396145-37411971 (-)
FVB/NJ MGP_FVBNJ_G0027934
 protein coding gene Chr4:36731264-36745929 (-)
LP/J MGP_LPJ_G0028075
 protein coding gene Chr4:39013843-39031585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027967
 protein coding gene Chr4:45086586-45104796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028623
 protein coding gene Chr4:38552654-38567567 (-)
PWK/PhJ MGP_PWKPhJ_G0027026
 protein coding gene Chr4:37405745-37416622 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026853
 protein coding gene Chr4:38243087-38258764 (-)
WSB/EiJ MGP_WSBEiJ_G0027383
 protein coding gene Chr4:38504283-38527237 (-)



Homology
more
  • Human Ortholog
    AQP7, aquaporin 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AQP7, aquaporin 7
  • Synonyms
    AQP7L, AQPap, GLYCQTL
  • Links
    NCBI Gene ID: 364
    neXtProt AC: NX_O14520
    UniProt: O14520

  • Chr Location
    9p13.3; chr9:33383179-33402682 (-)  GRCh38
  • Human Ortholog
    AQP7P3, aquaporin 7 pseudogene 3
  • Synonyms
    AQPap-3
  • Links
    NCBI Gene ID: 441432
    UniProt: A6NL99

  • Chr Location
    9q21.11; chr9:65877574-65912560 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 5 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice for one allele show decreased circulating glycerol levels and fasting hypoglycemia. Other mutant alleles show increased gonadal fat pad mass and adipocyte hypertrophy or increased urine glucose and impaired water permeability in the kidney, but have normal serum glycerol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    33
  • cDNA Data
    17
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028427 Ensembl Gene Model | MGI Sequence Detail 15066 C57BL/6J ±  kb
    transcript ENSMUST00000054945 Ensembl | MGI Sequence Detail 2154 Not Applicable  
    polypeptide ENSMUSP00000093007 Ensembl | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 17
      Primer pair 5
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:49128 Ishibashi K, et al., Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. Biochim Biophys Acta. 1998 Jul 30;1399(1):62-6
    • Latest
      J:347076 Fujii M, et al., Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice. Gen Thorac Cardiovasc Surg. 2023 Sep 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory