Hipk3 MGI Mouse Gene Detail - MGI:1314882 - homeodomain interacting protein kinase 3

Symbol

Hipk3
Name

homeodomain interacting protein kinase 3
Synonyms

DYRK6, FIST3

Feature Type

protein coding gene
IDs

MGI:1314882
NCBI Gene: 15259
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:104256826-104324791 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 54.74 cM

SNPs within 2kb

1248 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1314882	protein coding gene	Chr2:104256826-104324834 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026217	protein coding gene	Chr2:106528687-106608009 (-)
A/J	MGP_AJ_G0026178	protein coding gene	Chr2:102084066-102153494 (-)
AKR/J	MGP_AKRJ_G0026157	protein coding gene	Chr2:104856506-104930908 (-)
BALB/cJ	MGP_BALBcJ_G0026187	protein coding gene	Chr2:102368614-102436915 (-)
C3H/HeJ	MGP_C3HHeJ_G0025938	protein coding gene	Chr2:105182552-105253307 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026638	protein coding gene	Chr2:110032265-110107331 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024025	protein coding gene	Chr2:97895691-97963091 (-)
CAST/EiJ	MGP_CASTEiJ_G0025402	protein coding gene	Chr2:105668950-105752244 (-)
CBA/J	MGP_CBAJ_G0025915	protein coding gene	Chr2:113796831-113876165 (-)
DBA/2J	MGP_DBA2J_G0026053	protein coding gene	Chr2:101636029-101706219 (-)
FVB/NJ	MGP_FVBNJ_G0026015	protein coding gene	Chr2:100618155-100689403 (-)
LP/J	MGP_LPJ_G0026156	protein coding gene	Chr2:106630728-106704370 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026040	protein coding gene	Chr2:117688966-117760680 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026692	protein coding gene	Chr2:105061872-105135190 (-)
PWK/PhJ	MGP_PWKPhJ_G0025137	protein coding gene	Chr2:101162568-101233256 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024937	protein coding gene	Chr2:104284202-104360696 (-)
WSB/EiJ	MGP_WSBEiJ_G0025469	protein coding gene	Chr2:105794214-105865687 (-)

Human Ortholog

HIPK3, homeodomain interacting protein kinase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HIPK3, homeodomain interacting protein kinase 3
Synonyms

DYRK6, FIST3, PKY, YAK1
Links

HGNC:4915

NCBI Gene ID: 10114

neXtProt AC: NX_Q9H422

UniProt: Q9H422
Chr Location

11p13; chr11:33256672-33357023 (+) GRCh38

MGI Vertebrate Homology

Hipk3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HIPK3
Gene Tree

Hipk3

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Hipk3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit impaired insulin secretion and glucose tolerance.

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All GO Annotations

51
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

837
Tissues

14
cDNA Data

109
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HIPK3

Xenbase hipk3

ZFIN hipk3a

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All Sequences

52
RefSeq

4
UniProt

5
CCDS

CCDS16489.1

Ensembl

ENSMUSG00000027177 (Evidence)
NCBI Gene

15259

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027177	Ensembl Gene Model \| MGI Sequence Detail	67966	C57BL/6J	± kb
transcript	ENSMUST00000111125	Ensembl \| MGI Sequence Detail	3651	Not Applicable
polypeptide	ENSMUSP00000106754	Ensembl \| MGI Sequence Detail	1213	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008568 homeodomain-interacting protein kinase 3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 112

cDNA 110

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 51

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hipk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25528	Chr2:104325443-104325450 (-)	-656 bp
Tssr25527	Chr2:104324902-104324923 (-)	-122 bp
Tssr25526	Chr2:104324853-104324887 (-)	-79 bp
Tssr25525	Chr2:104324745-104324808 (-)	14 bp
Tssr25524	Chr2:104324728-104324740 (-)	57 bp
Tssr25523	Chr2:104324101-104324114 (-)	683 bp
Tssr25522	Chr2:104324087-104324098 (-)	698 bp
Tssr25521	Chr2:104323916-104323936 (-)	865 bp
Tssr25520	Chr2:104323708-104323729 (-)	1,072 bp
Tssr25519	Chr2:104323646-104323703 (-)	1,116 bp
Tssr25518	Chr2:104321677-104321681 (-)	3,112 bp
Tssr25517	Chr2:104271645-104271658 (-)	53,139 bp
Tssr25516	Chr2:104263982-104264004 (-)	60,798 bp
Tssr25514	Chr2:104257272-104257322 (-)	67,494 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24