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Tnfrsf1b Gene Detail
Summary
  • Symbol
    Tnfrsf1b
  • Name
    tumor necrosis factor receptor superfamily, member 1b
  • Synonyms
    CD120b, p75, p75 TNFR, TNF-alphaR2, TNFalpha-R2, TNFBR, Tnfr2, TNF-R2, TNF-R75, TNFR80, TNF-R-II, TNFRII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314883
    NCBI Gene: 21938
  • Alliance
    gene page
  • Transcription Start Sites
    50 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:144940033-144973440 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.17 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    859 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314883
 protein coding gene Chr4:144938938-144973453 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029102
 protein coding gene Chr4:148600198-148632151 (-)
A/J MGP_AJ_G0029069
 protein coding gene Chr4:142328837-142363036 (-)
AKR/J MGP_AKRJ_G0029017
 protein coding gene Chr4:146277456-146312809 (-)
BALB/cJ MGP_BALBcJ_G0029084
 protein coding gene Chr4:142969032-143002076 (-)
C3H/HeJ MGP_C3HHeJ_G0028803
 protein coding gene Chr4:146740581-146773687 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029529
 protein coding gene Chr4:153577277-153613116 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026781
 protein coding gene Chr4:135053704-135086676 (-)
CAST/EiJ MGP_CASTEiJ_G0028219
 protein coding gene Chr4:144802350-144835753 (-)
CBA/J MGP_CBAJ_G0028767
 protein coding gene Chr4:158445726-158484946 (-)
DBA/2J MGP_DBA2J_G0028915
 protein coding gene Chr4:142489400-142521822 (-)
FVB/NJ MGP_FVBNJ_G0028877
 protein coding gene Chr4:141619687-141654221 (-)
LP/J MGP_LPJ_G0029006
 protein coding gene Chr4:148644772-148678938 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028907
 protein coding gene Chr4:161956038-161989385 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029566
 protein coding gene Chr4:146783118-146815233 (-)
PWK/PhJ MGP_PWKPhJ_G0027939
 protein coding gene Chr4:138964527-138997238 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027773
 protein coding gene Chr4:142025021-142064458 (-)
WSB/EiJ MGP_WSBEiJ_G0028298
 protein coding gene Chr4:147032175-147064170 (-)



Homology
more
  • Human Ortholog
    TNFRSF1B, TNF receptor superfamily member 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF1B, TNF receptor superfamily member 1B
  • Synonyms
    CD120b, p75, p75TNFR, TBPII, TNFBR, TNFR1B, TNFR2, TNF-R75, TNFR80, TNF-R-II
  • Links
    NCBI Gene ID: 7133
    neXtProt AC: NX_P20333
    UniProt: P20333

  • Chr Location
    1p36.22; chr1:12166991-12209228 (+)  GRCh38
Human Diseases
more
  • Diseases
    12 with human TNFRSF1B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 5 alleles in 10 genetic backgrounds
    72 phenotypes from multigenic genotypes
    476 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered inflammatory responses in a variety of experimental conditions, impaired recovery from spinal cord injury, enhanced ischemia-reperfusion-induced retinal damage, and resistance to cerebral malaria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    73
  • cDNA Data
    59
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028599 Ensembl Gene Model | MGI Sequence Detail 33408 C57BL/6J ±  kb
    transcript ENSMUST00000030336 Ensembl | MGI Sequence Detail 3818 Not Applicable  
    polypeptide ENSMUSP00000030336 Ensembl | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 3
      cDNA 60
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15154, MGD-MRK-15157, MGI:98782
    References
    more
    • Summaries
      All 639
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 15
      Phenotypes 476
    • Earliest
      J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
    • Latest
      J:358825 Desu HL, et al., TNFR2 signaling in oligodendrocyte precursor cells suppresses their immune-inflammatory function and detrimental microglia activation in CNS demyelinating disease. Brain Behav Immun. 2024 Sep 5;123:81-98
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory