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Tnfrsf11a Gene Detail
Summary
  • Symbol
    Tnfrsf11a
  • Name
    tumor necrosis factor receptor superfamily, member 11a, NFKB activator
  • Synonyms
    Rank, TRANCE-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314891
    NCBI Gene: 21934
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:105708443-105775709 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 49.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1764 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314891
 protein coding gene Chr1:105708443-105777172 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016368
 protein coding gene Chr1:107901310-107974412 (+)
A/J MGP_AJ_G0016352
 protein coding gene Chr1:104140626-104206052 (+)
AKR/J MGP_AKRJ_G0016312
 protein coding gene Chr1:106997755-107068439 (+)
BALB/cJ MGP_BALBcJ_G0016308
 protein coding gene Chr1:104232541-104298767 (+)
C3H/HeJ MGP_C3HHeJ_G0016135
 protein coding gene Chr1:107433345-107499868 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016767
 protein coding gene Chr1:112048184-112121863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014485
 protein coding gene Chr1:98487003-98547275 (+)
CAST/EiJ MGP_CASTEiJ_G0015717
 protein coding gene Chr1:106341822-106409926 (+)
CBA/J MGP_CBAJ_G0016108
 protein coding gene Chr1:115844560-115927507 (+)
DBA/2J MGP_DBA2J_G0016213
 protein coding gene Chr1:103206364-103269634 (+)
FVB/NJ MGP_FVBNJ_G0016214
 protein coding gene Chr1:102148021-102215936 (+)
LP/J MGP_LPJ_G0016287
 protein coding gene Chr1:109169977-109240963 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016240
 protein coding gene Chr1:120331999-120397593 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016806
 protein coding gene Chr1:107074310-107141801 (+)
PWK/PhJ MGP_PWKPhJ_G0015504
 protein coding gene Chr1:102247132-102309155 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015289
 protein coding gene Chr1:105733403-105804923 (+)
WSB/EiJ MGP_WSBEiJ_G0015780
 protein coding gene Chr1:106911672-106976407 (+)



Homology
more
  • Human Ortholog
    TNFRSF11A, TNF receptor superfamily member 11a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF11A, TNF receptor superfamily member 11a
  • Synonyms
    CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCE-R, TRANCER
  • Links
    NCBI Gene ID: 8792
    neXtProt AC: NX_Q9Y6Q6
    UniProt: Q9Y6Q6

  • Chr Location
    18q21.33; chr18:62325287-62391288 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfrsf11a mouse models; 6 with human TNFRSF11A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 7 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or spontaneous allele exhibit a failure of tooth eruption, osteopetrosis, and abnormal immune system morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    22
  • cDNA Data
    15
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026321 Ensembl Gene Model | MGI Sequence Detail 67267 C57BL/6J ±  kb
    transcript ENSMUST00000027559 Ensembl | MGI Sequence Detail 5029 Not Applicable  
    polypeptide ENSMUSP00000027559 Ensembl | MGI Sequence Detail 625 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1194917
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 14
      Phenotypes 71
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:349716 Sandor LF, et al., De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis. Cell Rep. 2024 Mar 13;43(3):113936
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory