Spsb2 MGI Mouse Gene Detail - MGI:1315199 - splA/ryanodine receptor domain and SOCS box containing 2

Symbol

Spsb2
Name

splA/ryanodine receptor domain and SOCS box containing 2
Synonyms

Grcc9, SSB2

Feature Type

protein coding gene
IDs

MGI:1315199
NCBI Gene: 14794
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:124785640-124787582 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

3 experiments

SNPs within 2kb

131 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1315199	protein coding gene	Chr6:124785624-124787582 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031268	protein coding gene	Chr6:128115448-128117406 (+)
A/J	MGP_AJ_G0031238	protein coding gene	Chr6:123293969-123295927 (+)
AKR/J	MGP_AKRJ_G0031166	protein coding gene	Chr6:126658442-126660400 (+)
BALB/cJ	MGP_BALBcJ_G0031246	protein coding gene	Chr6:122894538-122896541 (+)
C3H/HeJ	MGP_C3HHeJ_G0030969	protein coding gene	Chr6:126705134-126707092 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031702	protein coding gene	Chr6:131499133-131501099 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028852	protein coding gene	Chr6:120504948-120506918 (+)
CAST/EiJ	MGP_CASTEiJ_G0030350	protein coding gene	Chr6:126908608-126910565 (+)
CBA/J	MGP_CBAJ_G0030930	protein coding gene	Chr6:136529466-136531424 (+)
DBA/2J	MGP_DBA2J_G0031086	protein coding gene	Chr6:122220823-122223508 (+)
FVB/NJ	MGP_FVBNJ_G0031036	protein coding gene	Chr6:121123554-121125512 (+)
LP/J	MGP_LPJ_G0031166	protein coding gene	Chr6:128285577-128287542 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031074	protein coding gene	Chr6:140589751-140591709 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031737	protein coding gene	Chr6:126552012-126553969 (+)
PWK/PhJ	MGP_PWKPhJ_G0030065	protein coding gene	Chr6:120449773-120451774 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029894	protein coding gene	Chr6:124632130-124634087 (+)
WSB/EiJ	MGP_WSBEiJ_G0030435	protein coding gene	Chr6:126911989-126913945 (+)

Human Ortholog

SPSB2, splA/ryanodine receptor domain and SOCS box containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPSB2, splA/ryanodine receptor domain and SOCS box containing 2
Synonyms

GRCC9, SSB2
Links

HGNC:29522

NCBI Gene ID: 84727

neXtProt AC: NX_Q99619

UniProt: Q99619
Chr Location

12p13.31; chr12:6870935-6889358 (-) GRCh38

MGI Vertebrate Homology

Spsb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPSB2
Gene Tree

Spsb2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit mild thrombocytopenia and decreased blood urea nitrogen levels.

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All GO Annotations

14
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

42

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

22
UniProt

3
CCDS

CCDS20529.1

Ensembl

ENSMUSG00000038451 (Evidence)
NCBI Gene

14794

			Length	Strain/Species	Flank
genomic	14794	NCBI Gene Model \| MGI Sequence Detail	1943	C57BL/6J	± kb
transcript	NM_013539	RefSeq \| MGI Sequence Detail	1217	ZRU/MplStud
polypeptide	O88838	UniProt \| EBI \| MGI Sequence Detail	264	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015587 SPRY domain-containing SOCS box protein 2

(term hierarchy)
PDB

2AFJ, 3EK9
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR050672 F-box/SPRY and SOCS box protein families

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

IPR003877 SPRY domain

IPR037340 SSB2, SOCS box domain

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All nucleic 43

Genomic 1

cDNA 42

Microarray probesets 3

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MGI:2141421

Summaries

All 38

Gene Ontology 9

Phenotypes 10
Earliest

J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Spsb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58846	Chr6:124785621-124785667 (+)	4 bp
Tssr58847	Chr6:124785861-124785896 (+)	239 bp
Tssr58848	Chr6:124785899-124785919 (+)	269 bp
Tssr58849	Chr6:124786687-124786723 (+)	1,065 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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