Lpcat3 MGI Mouse Gene Detail - MGI:1315211 - lysophosphatidylcholine acyltransferase 3

Symbol

Lpcat3
Name

lysophosphatidylcholine acyltransferase 3
Synonyms

Grcc3f, Mboat5, Oact5

Feature Type

protein coding gene
IDs

MGI:1315211
NCBI Gene: 14792
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:124639887-124681142 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

1 experiment

SNPs within 2kb

943 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1315211	protein coding gene	Chr6:124639887-124681381 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031259	protein coding gene	Chr6:127962954-128007976 (+)
A/J	MGP_AJ_G0031229	protein coding gene	Chr6:123153006-123194652 (+)
AKR/J	MGP_AKRJ_G0031157	protein coding gene	Chr6:126510740-126554190 (+)
BALB/cJ	MGP_BALBcJ_G0031237	protein coding gene	Chr6:122747663-122789488 (+)
C3H/HeJ	MGP_C3HHeJ_G0030960	protein coding gene	Chr6:126557839-126602739 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031693	protein coding gene	Chr6:131338716-131391453 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028843	protein coding gene	Chr6:120342748-120381349 (+)
CAST/EiJ	MGP_CASTEiJ_G0030341	protein coding gene	Chr6:126749740-126803926 (+)
CBA/J	MGP_CBAJ_G0030921	protein coding gene	Chr6:136375553-136422334 (+)
DBA/2J	MGP_DBA2J_G0031077	protein coding gene	Chr6:122077871-122121194 (+)
FVB/NJ	MGP_FVBNJ_G0031027	protein coding gene	Chr6:120982922-121024639 (+)
LP/J	MGP_LPJ_G0031157	protein coding gene	Chr6:128126983-128174936 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031065	protein coding gene	Chr6:140428676-140474006 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031728	protein coding gene	Chr6:126401577-126446170 (+)
PWK/PhJ	MGP_PWKPhJ_G0030056	protein coding gene	Chr6:120305774-120348856 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029885	protein coding gene	Chr6:124474735-124521075 (+)
WSB/EiJ	MGP_WSBEiJ_G0030426	protein coding gene	Chr6:126756479-126802921 (+)

Human Ortholog

LPCAT3, lysophosphatidylcholine acyltransferase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPCAT3, lysophosphatidylcholine acyltransferase 3
Synonyms

C3F, LPCAT, LPLAT12, LPLAT 5, LPSAT, MBOAT5, nessy, OACT5
Links

HGNC:30244

NCBI Gene ID: 10162

neXtProt AC: NX_Q6P1A2

UniProt: Q6P1A2
Chr Location

12p13.31; chr12:6976185-7018477 (-) GRCh38

MGI Vertebrate Homology

Lpcat3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPCAT3
Gene Tree

Lpcat3

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

4
Gene trapped

6
Targeted

9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show low blood glucose levels and postnatal death. Intestine-specific knockouts fail to thrive and show enterocyte lipid accumulation and low plasma triglycerides (TGs). Liver-specific knockouts show low plasma TGs, fatty liver, and secrete VLDL lacking arachidonoyl phospholipids.

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All GO Annotations

36
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

114
cDNA Data

117
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpcat3

ZFIN lpcat3

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All Sequences

63
RefSeq

9
UniProt

2
CCDS

CCDS20523.1

Ensembl

ENSMUSG00000004270 (Evidence)
NCBI Gene

14792

			Length	Strain/Species	Flank
genomic	14792	NCBI Gene Model \| MGI Sequence Detail	41256	C57BL/6J	± kb
transcript	NR_176913	RefSeq \| MGI Sequence Detail	1988	ZRU/MplStud
polypeptide	Q91V01	UniProt \| EBI \| MGI Sequence Detail	487	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009892 lysophospholipid acyltransferase 5

(term hierarchy)
EC

2.3.1.-, 2.3.1.23, 2.3.1.n6, 2.3.1.n7
InterPro Domains

IPR049941 Lysophospholipid acyltransferase 7/Porcupine-like

IPR004299 Membrane bound O-acyl transferase, MBOAT
GlyGen

Q91V01 3 sites

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All nucleic 119

Genomic 1

cDNA 117

Primer pair 1

Microarray probesets 2

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 24
Earliest

J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lpcat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58834	Chr6:124640048-124640049 (+)	162 bp
Tssr58835	Chr6:124640056-124640137 (+)	210 bp
Tssr58836	Chr6:124640152-124640175 (+)	277 bp
Tssr58837	Chr6:124678476-124678490 (+)	38,596 bp
Tssr58838	Chr6:124678586-124678600 (+)	38,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24