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Dhrs3 Gene Detail
Summary
  • Symbol
    Dhrs3
  • Name
    dehydrogenase/reductase 3
  • Synonyms
    dehydrogenase/reductase (SDR family) member 3, retSDR1, Rsdr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315215
    NCBI Gene: 20148
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:144619397-144654779 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    786 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315215
 protein coding gene Chr4:144618712-144654779 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029100
 protein coding gene Chr4:148255931-148294211 (+)
A/J MGP_AJ_G0029067
 protein coding gene Chr4:142004924-142039373 (+)
AKR/J MGP_AKRJ_G0029015
 protein coding gene Chr4:145951451-145988434 (+)
BALB/cJ MGP_BALBcJ_G0029082
 protein coding gene Chr4:142643523-142680019 (+)
C3H/HeJ MGP_C3HHeJ_G0028801
 protein coding gene Chr4:146413062-146447763 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029527
 protein coding gene Chr4:153237359-153279406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026779
 protein coding gene Chr4:134728169-134764117 (+)
CAST/EiJ MGP_CASTEiJ_G0028217
 protein coding gene Chr4:144464661-144499720 (+)
CBA/J MGP_CBAJ_G0028765
 protein coding gene Chr4:158096774-158140266 (+)
DBA/2J MGP_DBA2J_G0028913
 protein coding gene Chr4:142160549-142194336 (+)
FVB/NJ MGP_FVBNJ_G0028875
 protein coding gene Chr4:141297547-141331808 (+)
LP/J MGP_LPJ_G0029004
 protein coding gene Chr4:148312160-148350848 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028905
 protein coding gene Chr4:161619999-161656185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029564
 protein coding gene Chr4:146447188-146481100 (+)
PWK/PhJ MGP_PWKPhJ_G0027937
 protein coding gene Chr4:138637309-138671968 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027771
 protein coding gene Chr4:141679040-141714260 (+)
WSB/EiJ MGP_WSBEiJ_G0028296
 protein coding gene Chr4:146687078-146725233 (+)



Homology
more
  • Human Ortholog
    DHRS3, dehydrogenase/reductase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHRS3, dehydrogenase/reductase 3
  • Synonyms
    CNALPTC1, DD83.1, RDH17, retSDR1, Rsdr1, SDR1, SDR16C1
  • Links
    NCBI Gene ID: 9249
    neXtProt AC: NX_O75911
    UniProt: O75911

  • Chr Location
    1p36.21; chr1:12567909-12620133 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 4 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die before weaning age. Mice homozygous for a gene trap allele exhibit perinatal lethality, altered retinoid metabolism and heart, craniofacial and skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    144
  • cDNA Data
    56
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066026 Ensembl Gene Model | MGI Sequence Detail 35383 C57BL/6J ±  kb
    transcript ENSMUST00000154208 Ensembl | MGI Sequence Detail 2337 Not Applicable  
    polypeptide ENSMUSP00000122552 Ensembl | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 58
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:49273 Haeseleer F, et al., Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21;273(34):21790-9
    • Latest
      J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory