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Ahnak Gene Detail
Summary
  • Symbol
    Ahnak
  • Name
    AHNAK nucleoprotein
  • Synonyms
    1110004P15Rik, 2310047C17Rik, DY6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316648
    NCBI Gene: 66395
  • Alliance
    gene page
  • Transcription Start Sites
    49 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8966648-9054278 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.04 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1755 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316648
 protein coding gene Chr19:8966640-9054299 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024828
 protein coding gene Chr19:6277875-6373127 (+)
A/J MGP_AJ_G0024796
 protein coding gene Chr19:5943032-6030741 (+)
AKR/J MGP_AKRJ_G0024771
 protein coding gene Chr19:6044729-6138004 (+)
BALB/cJ MGP_BALBcJ_G0024796
 protein coding gene Chr19:6052250-6140413 (+)
C3H/HeJ MGP_C3HHeJ_G0024562
 protein coding gene Chr19:6130811-6231532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025243
 protein coding gene Chr19:6419757-6523738 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022672
 protein coding gene Chr19:6198881-6285364 (+)
CAST/EiJ MGP_CASTEiJ_G0024035
 protein coding gene Chr19:5784711-5886019 (+)
CBA/J MGP_CBAJ_G0024536
 protein coding gene Chr19:6535522-6629071 (+)
DBA/2J MGP_DBA2J_G0024663
 protein coding gene Chr19:5777759-5871932 (+)
FVB/NJ MGP_FVBNJ_G0024630
 protein coding gene Chr19:5848178-5929892 (+)
LP/J MGP_LPJ_G0024750
 protein coding gene Chr19:6176495-6276324 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024657
 protein coding gene Chr19:6396200-6481729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025292
 protein coding gene Chr19:6094984-6179986 (+)
PWK/PhJ MGP_PWKPhJ_G0023780
 protein coding gene Chr19:5450982-5549876 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023585
 protein coding gene Chr19:5700309-5789551 (+)
WSB/EiJ MGP_WSBEiJ_G0024097
 protein coding gene Chr19:6060612-6152152 (+)



Homology
more
  • Human Ortholog
    AHNAK, AHNAK nucleoprotein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AHNAK, AHNAK nucleoprotein
  • Synonyms
    AHNAK1, AHNAKRS, PM227
  • Links
    NCBI Gene ID: 79026
    neXtProt AC: NX_Q09666
    UniProt: Q09666

  • Chr Location
    11q12.3; chr11:62433542-62556235 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit decreased T cell proliferation and increased susceptibility to parasitic infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    141
  • cDNA Data
    20
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069833 Ensembl Gene Model | MGI Sequence Detail 87631 C57BL/6J ±  kb
    transcript ENSMUST00000092956 Ensembl | MGI Sequence Detail 18100 Not Applicable  
    polypeptide ENSMUSP00000090633 Ensembl | MGI Sequence Detail 5656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • InterPro Domains
      IPR001478 PDZ domain
      IPR036034 PDZ superfamily
      IPR052082 Peripheral myelin sheath structural protein
    • GlyGen
      E9Q616 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1913645, MGI:1920976, MGI:2147451, MGI:2147673
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 29
    • Earliest
      J:314095 Osborn M, et al., The submembranous location of p11 and its interaction with the p36 substrate of pp60 src kinase in situ. Exp Cell Res. 1988 Mar;175(1):81-96
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory