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St3gal3 Gene Detail
Summary
  • Symbol
    St3gal3
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3
  • Synonyms
    Siat3, Siat6, ST3Gal III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316659
    NCBI Gene: 20441
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117789351-117992111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.84 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6330 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316659
 protein coding gene Chr4:117789349-117992169 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028662
 protein coding gene Chr4:118937659-119161750 (-)
A/J MGP_AJ_G0028623
 protein coding gene Chr4:114352225-114560814 (-)
AKR/J MGP_AKRJ_G0028573
 protein coding gene Chr4:116855663-117068550 (-)
BALB/cJ MGP_BALBcJ_G0028644
 protein coding gene Chr4:114988491-115192704 (-)
C3H/HeJ MGP_C3HHeJ_G0028358
 protein coding gene Chr4:118430806-118637775 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029085
 protein coding gene Chr4:123515759-123736848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026369
 protein coding gene Chr4:108377784-108582482 (-)
CAST/EiJ MGP_CASTEiJ_G0027792
 protein coding gene Chr4:115658785-115884837 (-)
CBA/J MGP_CBAJ_G0028325
 protein coding gene Chr4:126886307-127114426 (-)
DBA/2J MGP_DBA2J_G0028473
 protein coding gene Chr4:114966963-115171074 (-)
FVB/NJ MGP_FVBNJ_G0028441
 protein coding gene Chr4:113482608-113686851 (-)
LP/J MGP_LPJ_G0028575
 protein coding gene Chr4:119126287-119346567 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028468
 protein coding gene Chr4:131803418-132035852 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029122
 protein coding gene Chr4:118002473-118227093 (-)
PWK/PhJ MGP_PWKPhJ_G0027518
 protein coding gene Chr4:111788026-112000825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027341
 protein coding gene Chr4:114314623-114527281 (-)
WSB/EiJ MGP_WSBEiJ_G0027871
 protein coding gene Chr4:117882741-118100362 (-)



Homology
more
  • Human Ortholog
    ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3
  • Synonyms
    DEE15, EIEE15, MRT12, SIAT6, ST3GALII, ST3Gal III, ST3GalIII, ST3N
  • Links
    NCBI Gene ID: 6487
    neXtProt AC: NX_Q11203
    UniProt: Q11203

  • Chr Location
    1p34.1; chr1:43705824-43931165 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ST3GAL3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Mice homozygous for disruptions in this gene show an apparently normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    130
  • cDNA Data
    41
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028538 Ensembl Gene Model | MGI Sequence Detail 202761 C57BL/6J ±  kb
transcript ENSMUST00000030263 Ensembl | MGI Sequence Detail 2549 Not Applicable  
polypeptide ENSMUSP00000030263 Ensembl | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 42
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
  • Latest
    J:334166 Gonzalez-Gil A, et al., Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. J Biol Chem. 2022 Apr 20;298(6):101960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory