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Rad1 Gene Detail
Summary
  • Symbol
    Rad1
  • Name
    RAD1 checkpoint DNA exonuclease
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316678
    NCBI Gene: 19355
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:10486104-10499149 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.35 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316678
 protein coding gene Chr15:10486104-10499149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021723
 protein coding gene Chr15:7624801-7638706 (+)
A/J MGP_AJ_G0021683
 protein coding gene Chr15:7418988-7432216 (+)
AKR/J MGP_AKRJ_G0021661
 protein coding gene Chr15:7594216-7607985 (+)
BALB/cJ MGP_BALBcJ_G0021690
 protein coding gene Chr15:7336285-7349129 (+)
C3H/HeJ MGP_C3HHeJ_G0021466
 protein coding gene Chr15:7540471-7553299 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022129
 protein coding gene Chr15:7909158-7923847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019666
 protein coding gene Chr15:6893504-6901876 (+)
CAST/EiJ MGP_CASTEiJ_G0020982
 protein coding gene Chr15:7595902-7611293 (+)
CBA/J MGP_CBAJ_G0021435
 protein coding gene Chr15:8093499-8108562 (+)
DBA/2J MGP_DBA2J_G0021559
 protein coding gene Chr15:7289716-7302725 (+)
FVB/NJ MGP_FVBNJ_G0021537
 protein coding gene Chr15:7150009-7164285 (+)
LP/J MGP_LPJ_G0021627
 protein coding gene Chr15:7522804-7536517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021562
 protein coding gene Chr15:8376689-8389561 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022152
 protein coding gene Chr15:7563232-7577416 (+)
PWK/PhJ MGP_PWKPhJ_G0020725
 protein coding gene Chr15:7453337-7466572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020563
 protein coding gene Chr15:7517367-7531934 (+)
WSB/EiJ MGP_WSBEiJ_G0021038
 protein coding gene Chr15:7568138-7582799 (+)



Homology
more
  • Human Ortholog
    RAD1, RAD1 checkpoint DNA exonuclease
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD1, RAD1 checkpoint DNA exonuclease
  • Synonyms
    HRAD1, REC1
  • Links
    NCBI Gene ID: 5810
    neXtProt AC: NX_O60671
    UniProt: O60671

  • Chr Location
    5p13.2; chr5:34905260-34918989 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit normal B cell DNA damage sensitivity, somatic hypermutation, and class switch recombination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    50
  • cDNA Data
    33
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19355 NCBI Gene Model | MGI Sequence Detail 13046 C57BL/6J ±  kb
    transcript NM_001289448 RefSeq | MGI Sequence Detail 4136 C57BL/6  
    polypeptide Q9QWZ1 UniProt | EBI | MGI Sequence Detail 280 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:49553 Freire R, et al., Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev. 1998 Aug 15;12(16):2560-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory