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Cox7a1 Gene Detail
Summary
  • Symbol
    Cox7a1
  • Name
    cytochrome c oxidase subunit 7A1
  • Synonyms
    COX7A, COX7AH, COX7AH, COX7AM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316714
    NCBI Gene: 12865
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:29883596-29885455 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316714
 protein coding gene Chr7:29883569-29885503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032004
 protein coding gene Chr7:29160096-29161953 (+)
A/J MGP_AJ_G0031981
 protein coding gene Chr7:28394658-28396498 (+)
AKR/J MGP_AKRJ_G0031914
 protein coding gene Chr7:29122902-29124742 (+)
BALB/cJ MGP_BALBcJ_G0031988
 protein coding gene Chr7:28570116-28571956 (+)
C3H/HeJ MGP_C3HHeJ_G0031707
 protein coding gene Chr7:29559426-29561283 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032453
 protein coding gene Chr7:30094237-30096094 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029504
 protein coding gene Chr7:29429991-29431639 (+)
CAST/EiJ MGP_CASTEiJ_G0031041
 protein coding gene Chr7:22808487-22810327 (+)
CBA/J MGP_CBAJ_G0031673
 protein coding gene Chr7:31548299-31550156 (+)
DBA/2J MGP_DBA2J_G0031825
 protein coding gene Chr7:28123590-28125430 (+)
FVB/NJ MGP_FVBNJ_G0031782
 protein coding gene Chr7:28235038-28236895 (+)
LP/J MGP_LPJ_G0031906
 protein coding gene Chr7:29484249-29486089 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031818
 protein coding gene Chr7:30816040-30817894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032482
 protein coding gene Chr7:28612979-28614833 (+)
PWK/PhJ MGP_PWKPhJ_G0030768
 protein coding gene Chr7:23150646-23152510 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030600
 protein coding gene Chr7:19610742-19612540 (+)
WSB/EiJ MGP_WSBEiJ_G0031151
 protein coding gene Chr7:28994110-28995974 (+)



Homology
more
  • Human Ortholog
    COX7A1, cytochrome c oxidase subunit 7A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX7A1, cytochrome c oxidase subunit 7A1
  • Synonyms
    COX7A, COX7AH, COX7AM
  • Links
    NCBI Gene ID: 1346
    neXtProt AC: NX_P24310
    UniProt: P24310

  • Chr Location
    19q13.12; chr19:36150922-36152449 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cox7a1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some premature death and dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    18
  • cDNA Data
    73
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12865 NCBI Gene Model | MGI Sequence Detail 1860 C57BL/6J ±  kb
    transcript NM_001412271 RefSeq | MGI Sequence Detail 460 ZRU/MplStud  
    polypeptide P56392 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005786 cytochrome c oxidase subunit 7A1, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR039297 Cytochrome c oxidase subunit VII
      IPR003177 Cytochrome c oxidase subunit VIIa, metazoa
      IPR036539 Cytochrome c oxidase, subunit VIIa superfamily
    • GlyGen
      P56392 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 73
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:47941 Jaradat SA, et al., Tissue-specific expression and mapping of the Cox7ah gene in mouse (Erratum: 1998;54(3):583-4). Genomics. 1998 May 1;49(3):363-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory