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G0s2 Gene Detail
Summary
  • Symbol
    G0s2
  • Name
    G0/G1 switch gene 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316737
    NCBI Gene: 14373
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:192954468-192955496 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 97.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316737
 protein coding gene Chr1:192954468-192955525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016963
 protein coding gene Chr1:200368215-200369271 (-)
A/J MGP_AJ_G0016942
 protein coding gene Chr1:192125529-192126589 (-)
AKR/J MGP_AKRJ_G0016907
 protein coding gene Chr1:197859857-197860914 (-)
BALB/cJ MGP_BALBcJ_G0016900
 protein coding gene Chr1:192818678-192819735 (-)
C3H/HeJ MGP_C3HHeJ_G0016724
 protein coding gene Chr1:198695827-198696887 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017363
 protein coding gene Chr1:206732076-206733132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015070
 protein coding gene Chr1:183001303-183002357 (-)
CAST/EiJ MGP_CASTEiJ_G0016307
 protein coding gene Chr1:198274752-198275782 (-)
CBA/J MGP_CBAJ_G0016698
 protein coding gene Chr1:214372905-214373962 (-)
DBA/2J MGP_DBA2J_G0016804
 protein coding gene Chr1:190842952-190844006 (-)
FVB/NJ MGP_FVBNJ_G0016800
 protein coding gene Chr1:188966912-188967972 (-)
LP/J MGP_LPJ_G0016879
 protein coding gene Chr1:201546499-201547555 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016832
 protein coding gene Chr1:221005924-221006984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017400
 protein coding gene Chr1:197675540-197676597 (-)
PWK/PhJ MGP_PWKPhJ_G0016094
 protein coding gene Chr1:190167798-190168852 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015870
 protein coding gene Chr1:196704114-196705164 (-)
WSB/EiJ MGP_WSBEiJ_G0016369
 protein coding gene Chr1:197966854-197967911 (-)



Homology
more
  • Human Ortholog
    G0S2, G0/G1 switch 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    G0S2, G0/G1 switch 2
  • Links
    NCBI Gene ID: 50486
    neXtProt AC: NX_P27469
    UniProt: P27469

  • Chr Location
    1q32.2; chr1:209675412-209676390 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are lean, glucose tolerant and insulin sensitive, and show reduced liver triglyceride levels, enhanced lipolysis, reduced white fat cell size, resistance to diet-induced obesity and liver steatosis, increased oxygen consumption and thermogenesis, and enhanced cold tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    3
  • cDNA Data
    86
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14373 NCBI Gene Model | MGI Sequence Detail 1029 C57BL/6J ±  kb
    transcript NM_008059 RefSeq | MGI Sequence Detail 847 ZRU/MplStud  
    polypeptide Q61585 UniProt | EBI | MGI Sequence Detail 103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 86

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138179, MGI:2138512
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:51222 Bachner D, et al., Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Dev Dyn. 1998 Dec;213(4):398-411
    • Latest
      J:337799 Corbet AK, et al., G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells. Transl Oncol. 2023 Jul;33:101676
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory