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Aurkc Gene Detail
Summary
  • Symbol
    Aurkc
  • Name
    aurora kinase C
  • Synonyms
    AIE1, AIK3, IAK3, Stk13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321119
    NCBI Gene: 20871
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:6998346-7006090 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 4.06 cM, cytoband A2-A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    8
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321119
 protein coding gene Chr7:6998299-7006090 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031630
 protein coding gene Chr7:8262958-8271803 (-)
A/J MGP_AJ_G0031590
 protein coding gene Chr7:3986121-3994871 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0031598
 protein coding gene Chr7:4097558-4104780 (+)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030693
 protein coding gene Chr7:6418083-6425275 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031402
 protein coding gene Chr7:8132249-8250942 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0032104
 protein coding gene Chr7:7973247-7983489 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030248
 protein coding gene Chr7:4873814-4905865 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AURKC, aurora kinase C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AURKC, aurora kinase C
  • Synonyms
    AIE2, AIK3, ARK3, AurC, aurora-C, HEL-S-90, SPGF5, STK13
  • Links
    NCBI Gene ID: 6795
    neXtProt AC: NX_Q9UQB9
    UniProt: Q9UQB9

  • Chr Location
    19q13.43; chr19:57231009-57235548 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AURKC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    17
  • cDNA Data
    11
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20871 NCBI Gene Model | MGI Sequence Detail 7745 C57BL/6J ±  kb
transcript NM_001080966 RefSeq | MGI Sequence Detail 1331 ZRU/MplStud  
polypeptide O88445 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 11
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:50717 Tseng TC, et al., Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 1998 Oct;17(10):823-33
  • Latest
    J:314136 Aboelenain M, et al., Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes. Development. 2021 Nov 1;148(21):dev199560
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory