Hint1 MGI Mouse Gene Detail - MGI:1321133 - histidine triad nucleotide binding protein 1

Symbol

Hint1
Name

histidine triad nucleotide binding protein 1
Synonyms

Ipk1, PKCI-1, PKC inhibitor/ interacting protein, PRKCNH1, protein kinase C inhibitor 1

Feature Type

protein coding gene
IDs

MGI:1321133
NCBI Gene: 15254
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:54757209-54761327 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM
Mapping Data

3 experiments

SNPs within 2kb

207 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321133	protein coding gene	Chr11:54757209-54761332 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018320	protein coding gene	Chr11:54354058-54358179 (+)
A/J	MGP_AJ_G0018289	protein coding gene	Chr11:52328949-52333067 (+)
AKR/J	MGP_AKRJ_G0018258	protein coding gene	Chr11:54048283-54052401 (+)
BALB/cJ	MGP_BALBcJ_G0018260	protein coding gene	Chr11:52674765-52678881 (+)
C3H/HeJ	MGP_C3HHeJ_G0018071	protein coding gene	Chr11:53980485-53984607 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018712	protein coding gene	Chr11:56015565-56019676 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016362	protein coding gene	Chr11:49765958-49770260 (+)
CAST/EiJ	MGP_CASTEiJ_G0017636	protein coding gene	Chr11:54025760-54029877 (+)
CBA/J	MGP_CBAJ_G0018046	protein coding gene	Chr11:58670368-58674479 (+)
DBA/2J	MGP_DBA2J_G0018155	protein coding gene	Chr11:52035800-52039918 (+)
FVB/NJ	MGP_FVBNJ_G0018147	protein coding gene	Chr11:51691420-51695534 (+)
LP/J	MGP_LPJ_G0018230	protein coding gene	Chr11:54808598-54812712 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018173	protein coding gene	Chr11:59885723-59891093 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018754	protein coding gene	Chr11:54057857-54061961 (+)
PWK/PhJ	MGP_PWKPhJ_G0017409	protein coding gene	Chr11:52579869-52583993 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017204	protein coding gene	Chr11:53851374-53855522 (+)
WSB/EiJ	MGP_WSBEiJ_G0017684	protein coding gene	Chr11:53694929-53699041 (+)

Human Ortholog

HINT1, histidine triad nucleotide binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HINT1, histidine triad nucleotide binding protein 1
Synonyms

HINT, NMAN, PKCI-1, PRKCNH1
Links

HGNC:4912

NCBI Gene ID: 3094

neXtProt AC: NX_P49773

UniProt: P49773
Chr Location

5q23.3; chr5:131155383-131224468 (-) GRCh38

MGI Vertebrate Homology

Hint1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: HINT1
Gene Tree

Hint1

Diseases

1 with human HINT1 associations

				Human Disease	Mouse Models
				Gamstorp-Wohlfart syndrome IDs Gamstorp-Wohlfart syndrome DOID:0050526 OMIM:137200

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

84
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

74
Targeted

7
Genomic Mutations

1 involving Hint1
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant animals do not exhibit an overt phenotype, though one line of mutant mice was shown to be more susceptible to carcinogen-induced tumors than wild-type.

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All GO Annotations

39
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

39
cDNA Data

151
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hint1

ZFIN hint1

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All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS24702.1

Ensembl

ENSMUSG00000020267 (Evidence)
NCBI Gene

15254

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020267	Ensembl Gene Model \| MGI Sequence Detail	4119	C57BL/6J	± kb
transcript	ENSMUST00000020504	Ensembl \| MGI Sequence Detail	636	Not Applicable
polypeptide	ENSMUSP00000020504	Ensembl \| MGI Sequence Detail	126	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008561 adenosine 5'-monophosphoramidase HINT1

(term hierarchy)
EC

3.4.22.-, 3.9.1.-
InterPro Domains

IPR019808 Histidine triad, conserved site

IPR001310 Histidine triad (HIT) protein

IPR011146 HIT-like domain

IPR036265 HIT-like superfamily
GlyGen

P70349 1 site, 1 O-linked glycan (1 site)

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All nucleic 153

cDNA 152

Primer pair 1

Microarray probesets 4

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MGI:2144040

Summaries

All 67

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hint1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101541	Chr11:54757200-54757218 (+)	0 bp
Tssr101542	Chr11:54757239-54757285 (+)	53 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24