Entpd3 MGI Mouse Gene Detail - MGI:1321386 - ectonucleoside triphosphate diphosphohydrolase 3

Symbol

Entpd3
Name

ectonucleoside triphosphate diphosphohydrolase 3
Synonyms

Cd39l3, HB6, NTPDase-3

Feature Type

protein coding gene
IDs

MGI:1321386
NCBI Gene: 215446
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:120368884-120397393 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 71.71 cM, cytoband F4
Mapping Data

2 experiments

SNPs within 2kb

801 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321386	protein coding gene	Chr9:120368884-120397393 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035436	protein coding gene	Chr9:123400007-123431982 (+)
A/J	MGP_AJ_G0035417	protein coding gene	Chr9:118758361-118787622 (+)
AKR/J	MGP_AKRJ_G0035350	protein coding gene	Chr9:121875702-121907095 (+)
BALB/cJ	MGP_BALBcJ_G0035413	protein coding gene	Chr9:118657655-118687628 (+)
C3H/HeJ	MGP_C3HHeJ_G0035121	protein coding gene	Chr9:122353757-122382082 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035936	protein coding gene	Chr9:126758015-126792354 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032818	protein coding gene	Chr9:115947913-115976489 (+)
CAST/EiJ	MGP_CASTEiJ_G0034425	protein coding gene	Chr9:122389389-122421179 (+)
CBA/J	MGP_CBAJ_G0035088	protein coding gene	Chr9:131458177-131488605 (+)
DBA/2J	MGP_DBA2J_G0035247	protein coding gene	Chr9:118216535-118245068 (+)
FVB/NJ	MGP_FVBNJ_G0035194	protein coding gene	Chr9:117104129-117133699 (+)
LP/J	MGP_LPJ_G0035326	protein coding gene	Chr9:123742535-123773971 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035235	protein coding gene	Chr9:132423104-132464684 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035955	protein coding gene	Chr9:122292660-122326093 (+)
PWK/PhJ	MGP_PWKPhJ_G0034130	protein coding gene	Chr9:118659619-118688837 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033966	protein coding gene	Chr9:122370811-122402618 (+)
WSB/EiJ	MGP_WSBEiJ_G0034545	protein coding gene	Chr9:122167864-122200528 (+)

Human Ortholog

ENTPD3, ectonucleoside triphosphate diphosphohydrolase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENTPD3, ectonucleoside triphosphate diphosphohydrolase 3
Synonyms

CD39L3, HB6, NTPDase-3
Links

HGNC:3365

NCBI Gene ID: 956

neXtProt AC: NX_O75355

UniProt: O75355
Chr Location

3p22.1; chr3:40387184-40428744 (+) GRCh38

MGI Vertebrate Homology

Entpd3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ENTPD3
Gene Tree

Entpd3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for a knock-out allele exhibit no deficits in nucleotide hydrolysis or alterations in nociceptive behaviors except for a modest reduction in beta-alanine-mediated itch behavior.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

981
Tissues

126
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase entpd3

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All Sequences

43
RefSeq

4
UniProt

2
CCDS

CCDS23629.1

Ensembl

ENSMUSG00000041608 (Evidence)
NCBI Gene

215446

			Length	Strain/Species	Flank
genomic	215446	NCBI Gene Model \| MGI Sequence Detail	28510	C57BL/6J	± kb
transcript	NM_178676	RefSeq \| MGI Sequence Detail	2920	C57BL/6
polypeptide	Q8BFW6	UniProt \| EBI \| MGI Sequence Detail	529	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007094 ectonucleoside triphosphate diphosphohydrolase 3

(term hierarchy)
EC

3.6.1.5
InterPro Domains

IPR000407 Nucleoside phosphatase GDA1/CD39
GlyGen

Q8BFW6 9 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 4

Summaries

All 34

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 4
Earliest

J:48684 Chadwick BP, et al., The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Genomics. 1998 Jun 15;50(3):357-67
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Entpd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87744	Chr9:120368867-120368930 (+)	15 bp
Tssr87745	Chr9:120368942-120368952 (+)	63 bp
Tssr87746	Chr9:120384651-120384654 (+)	15,769 bp
Tssr87747	Chr9:120384665-120384689 (+)	15,793 bp
Tssr87748	Chr9:120384704-120384713 (+)	15,825 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24