F11r MGI Mouse Gene Detail - MGI:1321398

Symbol

F11r
Name

F11 receptor
Synonyms

BV11 antigen, ESTM33, JAM-1, JAM-A, Jcam1, Ly106

Feature Type

protein coding gene
IDs

MGI:1321398
NCBI Gene: 16456
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:171265129-171292161 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.43 cM, cytoband H2
Mapping Data

5 experiments

SNPs within 2kb

801 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321398	protein coding gene	Chr1:171265103-171292171 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016763	protein coding gene	Chr1:177240949-177272811 (+)
A/J	MGP_AJ_G0016743	protein coding gene	Chr1:170014445-170042007 (+)
AKR/J	MGP_AKRJ_G0016709	protein coding gene	Chr1:175113410-175145524 (+)
BALB/cJ	MGP_BALBcJ_G0016704	protein coding gene	Chr1:170508672-170536057 (+)
C3H/HeJ	MGP_C3HHeJ_G0016527	protein coding gene	Chr1:175369739-175407546 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017165	protein coding gene	Chr1:183132830-183160951 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014873	protein coding gene	Chr1:161703143-161729475 (+)
CAST/EiJ	MGP_CASTEiJ_G0016108	protein coding gene	Chr1:174991856-175019921 (+)
CBA/J	MGP_CBAJ_G0016502	protein coding gene	Chr1:189645878-189684561 (+)
DBA/2J	MGP_DBA2J_G0016609	protein coding gene	Chr1:168856362-168884034 (+)
FVB/NJ	MGP_FVBNJ_G0016605	protein coding gene	Chr1:167208538-167237915 (+)
LP/J	MGP_LPJ_G0016680	protein coding gene	Chr1:178350384-178378254 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016632	protein coding gene	Chr1:196920195-196948033 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017202	protein coding gene	Chr1:174978434-175005363 (+)
PWK/PhJ	MGP_PWKPhJ_G0015894	protein coding gene	Chr1:168081480-168109810 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015678	protein coding gene	Chr1:173771483-173795775 (+)
WSB/EiJ	MGP_WSBEiJ_G0016170	protein coding gene	Chr1:175100007-175128027 (+)

Human Ortholog

F11R, F11 receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F11R, F11 receptor
Synonyms

CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1
Links

HGNC:14685

NCBI Gene ID: 50848

neXtProt AC: NX_Q9Y624

UniProt: Q9Y624
Chr Location

1q23.3; chr1:160995211-161021175 (-) GRCh38

MGI Vertebrate Homology

F11r stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: F11R
Gene Tree

F11r

Diseases

1 with human F11R associations

				Human Disease	Mouse Models
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 3 alleles in 2 genetic backgrounds
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

34
Targeted

4
Genomic Mutations

2 involving F11r
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

Homozygous null mice display increased dendritic cell migratory ability and contact hypersensitivity.

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All GO Annotations

57
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

908
Tissues

53
cDNA Data

101
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase f11r

ZFIN f11r.1, f11r.2

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS15496.1

Ensembl

ENSMUSG00000038235 (Evidence)
NCBI Gene

16456

			Length	Strain/Species	Flank
genomic	16456	NCBI Gene Model \| MGI Sequence Detail	27033	C57BL/6J	± kb
transcript	NM_172647	RefSeq \| MGI Sequence Detail	2482	ZRU/MplStud
polypeptide	O88792	UniProt \| EBI \| MGI Sequence Detail	300	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001871 junctional adhesion molecule A

(term hierarchy)
PDB

1F97
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR042456 Junctional adhesion molecule A
GlyGen

O88792 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 111

Genomic 3

cDNA 101

Primer pair 6

Other 1

Microarray probesets 3

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MGI:1334465

Summaries

All 112

Developmental Gene Expression 21

Gene Ontology 9

Phenotypes 46
Earliest

J:48708 Martin-Padura I, et al., Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol. 1998 Jul 13;142(1):117-27
Latest

J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777

TSS for F11r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10054	Chr1:171265120-171265134 (+)	-2 bp
Tssr10055	Chr1:171265136-171265152 (+)	15 bp
Tssr10056	Chr1:171265162-171265173 (+)	39 bp
Tssr290	Chr1:171266884-171266889 (+)	1,758 bp
Tssr10057	Chr1:171285673-171285687 (+)	20,551 bp
Tssr10058	Chr1:171285901-171285927 (+)	20,785 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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