Ly86 MGI Mouse Gene Detail - MGI:1321404

Symbol

Ly86
Name

lymphocyte antigen 86
Synonyms

MD-1, MD1

Feature Type

protein coding gene
IDs

MGI:1321404
NCBI Gene: 17084
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr13:37529276-37603012 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.70 cM

SNPs within 2kb

2517 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321404	protein coding gene	Chr13:37529184-37603012 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020465	protein coding gene	Chr13:35600913-35679197 (+)
A/J	MGP_AJ_G0020419	protein coding gene	Chr13:34506504-34582348 (+)
AKR/J	MGP_AKRJ_G0020397	protein coding gene	Chr13:35411510-35486436 (+)
BALB/cJ	MGP_BALBcJ_G0020415	protein coding gene	Chr13:34609313-34679434 (+)
C3H/HeJ	MGP_C3HHeJ_G0020214	protein coding gene	Chr13:35248629-35319610 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020848	protein coding gene	Chr13:36783916-36867090 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018435	protein coding gene	Chr13:32696382-32763994 (+)
CAST/EiJ	MGP_CASTEiJ_G0019729	protein coding gene	Chr13:34971456-35044910 (+)
CBA/J	MGP_CBAJ_G0020175	protein coding gene	Chr13:38358328-38431878 (+)
DBA/2J	MGP_DBA2J_G0020297	protein coding gene	Chr13:34033722-34107686 (+)
FVB/NJ	MGP_FVBNJ_G0020276	protein coding gene	Chr13:33565655-33637619 (+)
LP/J	MGP_LPJ_G0020372	protein coding gene	Chr13:35859492-35929858 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020306	protein coding gene	Chr13:38509642-38584789 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020891	protein coding gene	Chr13:34968626-35045518 (+)
PWK/PhJ	MGP_PWKPhJ_G0019484	protein coding gene	Chr13:34136089-34211036 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019315	protein coding gene	Chr13:33647464-33719124 (+)
WSB/EiJ	MGP_WSBEiJ_G0019791	protein coding gene	Chr13:35323408-35396254 (+)

Human Ortholog

LY86, lymphocyte antigen 86

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LY86, lymphocyte antigen 86
Synonyms

dJ80N2.1, MD-1, MD1, MMD-1
Links

HGNC:16837

NCBI Gene ID: 9450

neXtProt AC: NX_O95711

UniProt: O95711
Chr Location

6p25.1; chr6:6588108-6654983 (+) GRCh38

MGI Vertebrate Homology

Ly86 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LY86
Gene Tree

Ly86

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Ly86
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

17
cDNA Data

32
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ly86

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All Sequences

43
RefSeq

12
UniProt

2
CCDS

CCDS26457.1

Ensembl

ENSMUSG00000021423 (Evidence)
NCBI Gene

17084

			Length	Strain/Species	Flank
genomic	17084	NCBI Gene Model \| MGI Sequence Detail	73737	C57BL/6J	± kb
transcript	NM_010745	RefSeq \| MGI Sequence Detail	919	C57BL/6
polypeptide	O88188	UniProt \| EBI \| MGI Sequence Detail	162	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009997 lymphocyte antigen 86

(term hierarchy)
PDB

3M7O, 3T6Q
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR039945 Lymphocyte antigen 86

IPR003172 MD-2-related lipid-recognition domain
GlyGen

O88188 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 33

cDNA 32

Other 1

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 21
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:344350 Griffin EN, et al., RREB1 regulates neuronal proteostasis and the microtubule network. Sci Adv. 2024 Jan 12;10(2):eadh3929

TSS for Ly86:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119275	Chr13:37529264-37529279 (+)	-4 bp
Tssr119276	Chr13:37529314-37529341 (+)	52 bp
Tssr119277	Chr13:37529360-37529383 (+)	96 bp
Tssr119278	Chr13:37529391-37529408 (+)	124 bp
Tssr119279	Chr13:37529433-37529456 (+)	169 bp
Tssr119280	Chr13:37560594-37560617 (+)	31,330 bp
Tssr119281	Chr13:37560900-37560921 (+)	31,635 bp
Tssr119282	Chr13:37562510-37562521 (+)	33,240 bp
Tssr119283	Chr13:37562552-37562564 (+)	33,282 bp
Tssr119284	Chr13:37562671-37562688 (+)	33,404 bp
Tssr119285	Chr13:37562771-37562804 (+)	33,512 bp
Tssr119286	Chr13:37584978-37584981 (+)	55,704 bp
Tssr119287	Chr13:37587953-37587963 (+)	58,682 bp
Tssr119288	Chr13:37599468-37599497 (+)	70,207 bp
Tssr119289	Chr13:37602511-37602524 (+)	73,242 bp
Tssr119290	Chr13:37602638-37602661 (+)	73,374 bp
Tssr119291	Chr13:37602739-37602769 (+)	73,478 bp
Tssr119292	Chr13:37602818-37602836 (+)	73,551 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24