Zc3h7b MGI Mouse Gene Detail - MGI:1328310 - zinc finger CCCH type containing 7B

Symbol

Zc3h7b
Name

zinc finger CCCH type containing 7B
Synonyms

Scrg3

Feature Type

protein coding gene
IDs

MGI:1328310
NCBI Gene: 20286
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:81629299-81680470 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.23 cM
Mapping Data

2 experiments

SNPs within 2kb

1430 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328310	protein coding gene	Chr15:81629258-81680470 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022119	protein coding gene	Chr15:82203571-82257476 (+)
A/J	MGP_AJ_G0022080	protein coding gene	Chr15:79301115-79359438 (+)
AKR/J	MGP_AKRJ_G0022055	protein coding gene	Chr15:81497813-81551274 (+)
BALB/cJ	MGP_BALBcJ_G0022086	protein coding gene	Chr15:79345698-79398471 (+)
C3H/HeJ	MGP_C3HHeJ_G0021857	protein coding gene	Chr15:81516103-81572268 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022529	protein coding gene	Chr15:85432510-85495015 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020058	protein coding gene	Chr15:75757972-75806555 (+)
CAST/EiJ	MGP_CASTEiJ_G0021377	protein coding gene	Chr15:82285296-82340427 (+)
CBA/J	MGP_CBAJ_G0021821	protein coding gene	Chr15:88087613-88147875 (+)
DBA/2J	MGP_DBA2J_G0021951	protein coding gene	Chr15:78779232-78830318 (+)
FVB/NJ	MGP_FVBNJ_G0021928	protein coding gene	Chr15:77818126-77870262 (+)
LP/J	MGP_LPJ_G0022019	protein coding gene	Chr15:82352532-82408189 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021949	protein coding gene	Chr15:93032719-93093044 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022543	protein coding gene	Chr15:81592080-81647291 (+)
PWK/PhJ	MGP_PWKPhJ_G0021119	protein coding gene	Chr15:78817780-78870902 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020956	protein coding gene	Chr15:81385411-81436881 (+)
WSB/EiJ	MGP_WSBEiJ_G0021429	protein coding gene	Chr15:82010000-82062181 (+)

Human Ortholog

ZC3H7B, zinc finger CCCH-type containing 7B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3H7B, zinc finger CCCH-type containing 7B
Synonyms

RoXaN, ROXAN1
Links

HGNC:30869

NCBI Gene ID: 23264

neXtProt AC: NX_Q9UGR2

UniProt: Q9UGR2
Chr Location

22q13.2; chr22:41301525-41360147 (+) GRCh38

MGI Vertebrate Homology

Zc3h7b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZC3H7B
Gene Tree

Zc3h7b

less

References

1 with disease annotations

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

15
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Zc3h7b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available

less

All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

119
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zc3h7b

less

All Sequences

51
RefSeq

4
UniProt

5
CCDS

CCDS37150.1

Ensembl

ENSMUSG00000022390 (Evidence)
NCBI Gene

20286

			Length	Strain/Species	Flank
genomic	20286	NCBI Gene Model \| MGI Sequence Detail	51172	C57BL/6J	± kb
transcript	NM_001081016	RefSeq \| MGI Sequence Detail	5699	C57BL/6
polypeptide	NP_001074485	RefSeq \| MGI Sequence Detail	982	C57BL/6

less

UniProt

5 Sequences
InterPro Domains

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR036236 Zinc finger C2H2 superfamily

IPR039691 Zinc finger CCCH domain-containing protein A/B

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily
GlyGen

F8VPP8 1 site, 1 N-linked glycan (1 site)

less

All nucleic 121

Genomic 2

cDNA 119

Microarray probesets 4

less

MGI:2685473

Summaries

All 53

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zc3h7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132291	Chr15:81629243-81629252 (+)	-51 bp
Tssr132292	Chr15:81629258-81629332 (+)	-4 bp
Tssr132293	Chr15:81629340-81629370 (+)	56 bp
Tssr132294	Chr15:81629373-81629389 (+)	82 bp
Tssr132295	Chr15:81656492-81656521 (+)	27,208 bp
Tssr132296	Chr15:81656534-81656547 (+)	27,242 bp
Tssr132297	Chr15:81660473-81660480 (+)	31,178 bp
Tssr132298	Chr15:81660494-81660523 (+)	31,210 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24