Krtap12-1 Gene Detail

Summary

• Symbol
  Krtap12-1
• Name
  keratin associated protein 12-1
• Synonyms
  D10Jhu14e

• Feature Type
  protein coding gene
• IDs
  MGI:1328315
  NCBI Gene: 16694
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr10:77556433-77557088 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 39.72 cM
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  102 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328315	protein coding gene	Chr10:77556420-77557090 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017406	protein coding gene	Chr10:78065708-78066378 (+)
A/J	MGP_AJ_G0017382	protein coding gene	Chr10:75345101-75345771 (+)
AKR/J	MGP_AKRJ_G0017344	protein coding gene	Chr10:77355157-77355827 (+)
BALB/cJ	MGP_BALBcJ_G0017343	protein coding gene	Chr10:75539212-75539882 (+)
C3H/HeJ	MGP_C3HHeJ_G0017167	protein coding gene	Chr10:77438815-77439485 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017801	protein coding gene	Chr10:80814883-80815553 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015490	protein coding gene	Chr10:71776636-71777306 (+)
CAST/EiJ	MGP_CASTEiJ_G0016737	protein coding gene	Chr10:77805554-77806236 (+)
CBA/J	MGP_CBAJ_G0017139	protein coding gene	Chr10:83913832-83914589 (+)
DBA/2J	MGP_DBA2J_G0017244	protein coding gene	Chr10:74620849-74621519 (+)
FVB/NJ	MGP_FVBNJ_G0017236	protein coding gene	Chr10:73798745-73799472 (+)
LP/J	MGP_LPJ_G0017317	protein coding gene	Chr10:78526642-78527312 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017265	protein coding gene	Chr10:85949948-85950618 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017840	protein coding gene	Chr10:77446120-77447286 (+)
PWK/PhJ	MGP_PWKPhJ_G0016520	protein coding gene	Chr10:74504812-74505668 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016304	protein coding gene	Chr10:76697566-76698206 (+)
WSB/EiJ	MGP_WSBEiJ_G0016799	protein coding gene	Chr10:77417907-77418577 (+)

Homology

• Human Ortholog
  KRTAP12-1, keratin associated protein 12-1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP12-1, keratin associated protein 12-1
  
• Synonyms
  KAP12.1, KRTAP12.1
• Links
  HGNC:20529

  NCBI Gene ID: 353332

  neXtProt AC: NX_P59990

  UniProt: P59990

  
  
• Chr Location
  21q22.3; chr21:44681576-44682163 (-)  GRCh38

---

• Human Ortholog
  KRTAP12-2, keratin associated protein 12-2
  
• Synonyms
  KAP12.2, KRTAP12.2
• Links
  HGNC:20530

  NCBI Gene ID: 353323

  neXtProt AC: NX_P59991

  UniProt: P59991

  
  
• Chr Location
  21q22.3; chr21:44666189-44666927 (-)  GRCh38

---

• Human Ortholog
  KRTAP12-3, keratin associated protein 12-3
  
• Synonyms
  KRTAP12.3
• Links
  HGNC:20531

  NCBI Gene ID: 386683

  neXtProt AC: NX_P60328

  UniProt: P60328

  
  
• Chr Location
  21q22.3; chr21:44657932-44658341 (+)  GRCh38

---

• MGI Vertebrate Homology
  Krtap12-1 stringent orthology
  3 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: KRTAP12-1, KRTAP12-2, KRTAP12-3
• Gene Tree
  Krtap12-1
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  30 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  4 involving Krtap12-1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  3

Expression

• Assay Results
  865
• Tissues
  131
• cDNA Data
  6
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS23959.1

• Ensembl
  ENSMUSG00000069583 (Evidence)
• NCBI Gene
  16694

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000069583	Ensembl Gene Model | MGI Sequence Detail	656	C57BL/6J
transcript	ENSMUST00000092370	Ensembl | MGI Sequence Detail	656	Not Applicable
polypeptide	ENSMUSP00000090024	Ensembl | MGI Sequence Detail	130	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR002494 Keratin-associated protein

Molecular
Reagents

• All nucleic 25

  Genomic 16

  cDNA 6

  Primer pair 2

  Other 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1336210, MGI:2143634, MGI:2143649

References

• Summaries
  All 56

  Developmental Gene Expression 3

  Diseases 2

  Gene Ontology 3

  Phenotypes 30
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Krtap12-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94284	Chr10:77556418-77556427 (+)	-10 bp