Cd83 MGI Mouse Gene Detail - MGI:1328316

Symbol

Cd83
Name

CD83 antigen

Feature Type

protein coding gene
IDs

MGI:1328316
NCBI Gene: 12522
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:43938661-43956608 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 21.60 cM, cytoband A4-5
Mapping Data

3 experiments

SNPs within 2kb

571 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328316	protein coding gene	Chr13:43938251-43956608 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020503	protein coding gene	Chr13:42401473-42419506 (+)
A/J	MGP_AJ_G0020457	protein coding gene	Chr13:40955518-40973551 (+)
AKR/J	MGP_AKRJ_G0020435	protein coding gene	Chr13:42086113-42104133 (+)
BALB/cJ	MGP_BALBcJ_G0020453	protein coding gene	Chr13:41167740-41185759 (+)
C3H/HeJ	MGP_C3HHeJ_G0020252	protein coding gene	Chr13:41950252-41968347 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020886	protein coding gene	Chr13:43707071-43725094 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018473	protein coding gene	Chr13:39052613-39071003 (+)
CAST/EiJ	MGP_CASTEiJ_G0019767	protein coding gene	Chr13:41801428-41844836 (+)
CBA/J	MGP_CBAJ_G0020213	protein coding gene	Chr13:45546845-45564866 (+)
DBA/2J	MGP_DBA2J_G0020335	protein coding gene	Chr13:40521454-40539459 (+)
FVB/NJ	MGP_FVBNJ_G0020314	protein coding gene	Chr13:40042930-40061141 (+)
LP/J	MGP_LPJ_G0020410	protein coding gene	Chr13:42645678-42663767 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020343	protein coding gene	Chr13:45462613-45480642 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020929	protein coding gene	Chr13:41764549-41782569 (+)
PWK/PhJ	MGP_PWKPhJ_G0019522	protein coding gene	Chr13:40636181-40654308 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019352	protein coding gene	Chr13:40382885-40402110 (+)
WSB/EiJ	MGP_WSBEiJ_G0019829	protein coding gene	Chr13:42061163-42079233 (+)

Human Ortholog

CD83, CD83 molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD83, CD83 molecule
Synonyms

BL11, HB15
Links

HGNC:1703

NCBI Gene ID: 9308

neXtProt AC: NX_Q01151

UniProt: Q01151
Chr Location

6p23; chr6:14117256-14136918 (+) GRCh38

MGI Vertebrate Homology

Cd83 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD83
Gene Tree

Cd83

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Phenotype Summary

18 phenotypes from 6 alleles in 6 genetic backgrounds
2 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

1 involving Cd83
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice lacking this gene develop, thrive, and reproduce normally, but exhibit defects in T cell development.

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All GO Annotations

10
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

35
cDNA Data

41
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

4
UniProt

2
CCDS

CCDS26481.1

Ensembl

ENSMUSG00000015396 (Evidence)
NCBI Gene

12522

			Length	Strain/Species	Flank
genomic	12522	NCBI Gene Model \| MGI Sequence Detail	17948	C57BL/6J	± kb
transcript	NM_009856	RefSeq \| MGI Sequence Detail	2067	ZRU/MplStud
polypeptide	O88324	UniProt \| EBI \| MGI Sequence Detail	196	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001310 CD83 molecule

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

O88324 3 sites, 2 N-linked glycans (3 sites)

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All nucleic 48

Genomic 3

cDNA 41

Primer pair 2

Other 2

Microarray probesets 4

Summaries

All 69

Developmental Gene Expression 8

Gene Ontology 1

Phenotypes 31
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cd83:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119516	Chr13:43938616-43938636 (+)	-35 bp
Tssr119517	Chr13:43938644-43938679 (+)	1 bp
Tssr119518	Chr13:43944505-43944529 (+)	5,856 bp
Tssr119519	Chr13:43951075-43951094 (+)	12,424 bp
Tssr119520	Chr13:43951360-43951373 (+)	12,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24