Syngr2 MGI Mouse Gene Detail - MGI:1328324

Symbol

Syngr2
Name

synaptogyrin 2
Synonyms

cellugyrin, Clast2

Feature Type

protein coding gene
IDs

MGI:1328324
NCBI Gene: 20973
Alliance

gene page

Sequence Map

Chr11:117700494-117705109 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM
Mapping Data

1 experiment

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328324	protein coding gene	Chr11:117700459-117705112 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019453	protein coding gene	Chr11:122091704-122096319 (+)
A/J	MGP_AJ_G0019421	protein coding gene	Chr11:116680699-116685314 (+)
AKR/J	MGP_AKRJ_G0019391	protein coding gene	Chr11:120233043-120237658 (+)
BALB/cJ	MGP_BALBcJ_G0019396	protein coding gene	Chr11:117052608-117057207 (+)
C3H/HeJ	MGP_C3HHeJ_G0019202	protein coding gene	Chr11:120514647-120519262 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019845	protein coding gene	Chr11:125817903-125822502 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017469	protein coding gene	Chr11:113689488-113694115 (+)
CAST/EiJ	MGP_CASTEiJ_G0018755	protein coding gene	Chr11:121943400-121948074 (+)
CBA/J	MGP_CBAJ_G0019173	protein coding gene	Chr11:130772087-130776702 (+)
DBA/2J	MGP_DBA2J_G0019285	protein coding gene	Chr11:116081778-116086393 (+)
FVB/NJ	MGP_FVBNJ_G0019277	protein coding gene	Chr11:115701519-115706118 (+)
LP/J	MGP_LPJ_G0019355	protein coding gene	Chr11:122416324-122420939 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019310	protein coding gene	Chr11:129732313-129736903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019884	protein coding gene	Chr11:120882302-120886917 (+)
PWK/PhJ	MGP_PWKPhJ_G0018522	protein coding gene	Chr11:117437542-117442163 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018314	protein coding gene	Chr11:120613722-120618315 (+)
WSB/EiJ	MGP_WSBEiJ_G0018808	protein coding gene	Chr11:120849239-120853860 (+)

Human Ortholog

SYNGR2, synaptogyrin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYNGR2, synaptogyrin 2
Links

HGNC:11499

NCBI Gene ID: 9144

neXtProt AC: NX_O43760

UniProt: O43760
Chr Location

17q25.3; chr17:78168545-78173527 (+) GRCh38

MGI Vertebrate Homology

Syngr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SYNGR2
Protein SuperFamily

Synaptogyrin
Gene Tree

Syngr2

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

8
cDNA Data

230
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syngr2

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All Sequences

72
RefSeq

4
UniProt

6
CCDS

CCDS25691.1

Ensembl

ENSMUSG00000048277 (Evidence)
NCBI Gene

20973

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048277	Ensembl Gene Model \| MGI Sequence Detail	4616	C57BL/6J	± kb
transcript	ENSMUST00000026649	Ensembl \| MGI Sequence Detail	1520	Not Applicable
polypeptide	ENSMUSP00000026649	Ensembl \| MGI Sequence Detail	224	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015879 synaptogyrin-2

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR016579 Synaptogyrin

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All nucleic 234

cDNA 234

Microarray probesets 4

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 5
Earliest

J:50126 Kedra D, et al., Characterization of the human synaptogyrin gene family. Hum Genet. 1998 Aug;103(2):131-41
Latest

J:234039 Beaton N, et al., TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. Mol Metab. 2015 Nov;4(11):795-810

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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