Map7 MGI Mouse Gene Detail - MGI:1328328 - microtubule-associated protein 7

Symbol

Map7
Name

microtubule-associated protein 7
Synonyms

E-MAP-115, mshi, mste, Mtap7, ste

Feature Type

protein coding gene
IDs

MGI:1328328
NCBI Gene: 17761
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr10:20024666-20157336 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 9.75 cM
Mapping Data

11 experiments

SNPs within 2kb

4232 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328328	protein coding gene	Chr10:20024217-20157336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017052	protein coding gene	Chr10:17883514-18021069 (+)
A/J	MGP_AJ_G0017030	protein coding gene	Chr10:17199368-17334651 (+)
AKR/J	MGP_AKRJ_G0016994	protein coding gene	Chr10:17504493-17641640 (+)
BALB/cJ	MGP_BALBcJ_G0016988	protein coding gene	Chr10:17269182-17405670 (+)
C3H/HeJ	MGP_C3HHeJ_G0016813	protein coding gene	Chr10:17825124-17960743 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017450	protein coding gene	Chr10:18331995-18475823 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015155	protein coding gene	Chr10:16197940-16331205 (+)
CAST/EiJ	MGP_CASTEiJ_G0016395	protein coding gene	Chr10:17691075-17834418 (+)
CBA/J	MGP_CBAJ_G0016785	protein coding gene	Chr10:19158334-19304284 (+)
DBA/2J	MGP_DBA2J_G0016893	protein coding gene	Chr10:17084843-17220121 (+)
FVB/NJ	MGP_FVBNJ_G0016888	protein coding gene	Chr10:16839572-16974207 (+)
LP/J	MGP_LPJ_G0016968	protein coding gene	Chr10:17683121-17821382 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016918	protein coding gene	Chr10:19406646-19551258 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017488	protein coding gene	Chr10:17489958-17628068 (+)
PWK/PhJ	MGP_PWKPhJ_G0016180	protein coding gene	Chr10:16959885-17096177 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015963	protein coding gene	Chr10:17632678-17775753 (+)
WSB/EiJ	MGP_WSBEiJ_G0016457	protein coding gene	Chr10:17576805-17713295 (+)

Human Ortholog

MAP7, microtubule associated protein 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP7, microtubule associated protein 7
Synonyms

E-MAP-115, EMAP115
Links

HGNC:6869

NCBI Gene ID: 9053

neXtProt AC: NX_Q14244

UniProt: Q14244
Chr Location

6q23.3; chr6:136342281-136550819 (-) GRCh38

MGI Vertebrate Homology

Map7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAP7
Gene Tree

Map7

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Phenotype Summary

16 phenotypes from 2 alleles in 5 genetic backgrounds
1 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

178
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

168
Spontaneous

2
Targeted

4
Genomic Mutations

2 involving Map7
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

240 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for mutations in this marker are sterile with small, disorganized testes, small epidiymis and seminiferous tubules. They have deformed spermatid nuclei and a block in spermatogenesis. Aberrant microtubules are seen in elongating spermatids and sertoli cells.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

894
Tissues

113
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map7

ZFIN map7b

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All Sequences

101
RefSeq

42
UniProt

6
CCDS

CCDS56694.1, CCDS87968.1

Ensembl

ENSMUSG00000019996 (Evidence)
NCBI Gene

17761

			Length	Strain/Species	Flank
genomic	17761	NCBI Gene Model \| MGI Sequence Detail	132671	C57BL/6J	± kb
transcript	NM_001428647	RefSeq \| MGI Sequence Detail	4034	C57BL/6
polypeptide	O88735	UniProt \| EBI \| MGI Sequence Detail	730	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010149 ensconsin

(term hierarchy)
InterPro Domains

IPR051483 Microtubule-associated protein 7 domain-containing protein

IPR008604 Microtubule-associated protein 7 family

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All nucleic 20

cDNA 17

Primer pair 3

Microarray probesets 5

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MGD-MRK-12569, MGD-MRK-14620, MGD-MRK-35074, MGI:106617, MGI:2143958

Summaries

All 59

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 26
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67

TSS for Map7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92568	Chr10:20024203-20024224 (+)	-452 bp
Tssr92569	Chr10:20024423-20024434 (+)	-237 bp
Tssr92570	Chr10:20024439-20024451 (+)	-221 bp
Tssr3154	Chr10:20024634-20024647 (+)	-25 bp
Tssr92571	Chr10:20024724-20024760 (+)	76 bp
Tssr92572	Chr10:20046471-20046504 (+)	21,822 bp
Tssr92573	Chr10:20046507-20046542 (+)	21,859 bp
Tssr92574	Chr10:20046549-20046567 (+)	21,892 bp
Tssr92575	Chr10:20046569-20046580 (+)	21,909 bp
Tssr92576	Chr10:20046749-20046791 (+)	22,104 bp
Tssr92577	Chr10:20046835-20046846 (+)	22,175 bp
Tssr92578	Chr10:20047648-20047673 (+)	22,995 bp
Tssr92579	Chr10:20047702-20047721 (+)	23,046 bp
Tssr92580	Chr10:20047747-20047758 (+)	23,087 bp
Tssr92581	Chr10:20061170-20061171 (+)	36,505 bp
Tssr92582	Chr10:20079351-20079362 (+)	54,691 bp
Tssr92583	Chr10:20080605-20080646 (+)	55,960 bp
Tssr92584	Chr10:20080995-20081028 (+)	56,346 bp
Tssr92585	Chr10:20081041-20081069 (+)	56,389 bp
Tssr92586	Chr10:20081102-20081112 (+)	56,441 bp
Tssr92588	Chr10:20105508-20105510 (+)	80,843 bp
Tssr92589	Chr10:20105525-20105548 (+)	80,871 bp
Tssr92590	Chr10:20142965-20142975 (+)	118,304 bp
Tssr92591	Chr10:20142990-20143012 (+)	118,335 bp
Tssr92592	Chr10:20143014-20143056 (+)	118,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24