About   Help   FAQ
Matn3 Gene Detail
Summary
  • Symbol
    Matn3
  • Name
    matrilin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328350
    NCBI Gene: 17182
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8997929-9022028 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 3.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    720 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328350
 protein coding gene Chr12:8997929-9022028 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019590
 protein coding gene Chr12:6033963-6060173 (+)
A/J MGP_AJ_G0019557
 protein coding gene Chr12:5860206-5883525 (+)
AKR/J MGP_AKRJ_G0019527
 protein coding gene Chr12:6249838-6273804 (+)
BALB/cJ MGP_BALBcJ_G0019532
 protein coding gene Chr12:5987379-6014064 (+)
C3H/HeJ MGP_C3HHeJ_G0019338
 protein coding gene Chr12:6082159-6107821 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019981
 protein coding gene Chr12:6222344-6246518 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017606
 protein coding gene Chr12:5668742-5690175 (+)
CAST/EiJ MGP_CASTEiJ_G0018893
 protein coding gene Chr12:6075172-6098702 (+)
CBA/J MGP_CBAJ_G0019309
 protein coding gene Chr12:6767207-6794847 (+)
DBA/2J MGP_DBA2J_G0019422
 protein coding gene Chr12:5809365-5832971 (+)
FVB/NJ MGP_FVBNJ_G0019413
 protein coding gene Chr12:5785168-5809345 (+)
LP/J MGP_LPJ_G0019493
 protein coding gene Chr12:6080722-6113021 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019446
 protein coding gene Chr12:6568396-6594589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020020
 protein coding gene Chr12:5997377-6021930 (+)
PWK/PhJ MGP_PWKPhJ_G0018659
 protein coding gene Chr12:5878516-5901959 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018450
 protein coding gene Chr12:5998894-6024142 (+)
WSB/EiJ MGP_WSBEiJ_G0018944
 protein coding gene Chr12:6050947-6075728 (+)



Homology
more
  • Human Ortholog
    MATN3, matrilin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATN3, matrilin 3
  • Synonyms
    DIPOA, EDM5, HOA, OADIP, OS2, SEMDBCD
  • Links
    NCBI Gene ID: 4148
    neXtProt AC: NX_O15232
    UniProt: O15232

  • Chr Location
    2p24.1; chr2:19992052-20012668 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Matn3 mouse models; 3 with human MATN3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    42
  • cDNA Data
    9
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17182 NCBI Gene Model | MGI Sequence Detail 24100 C57BL/6J ±  kb
    transcript NM_010770 RefSeq | MGI Sequence Detail 3014 ZRU/MplStud  
    polypeptide O35701 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144975
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:51112 Wagener R, et al., Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 1997 Aug 11;413(1):129-34
    • Latest
      J:348599 Zhou X, et al., Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation. Cell Rep. 2024 Mar 21;43(4):113980
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory