Mpp3 MGI Mouse Gene Detail - MGI:1328354 - membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

Symbol

Mpp3
Name

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms

Dlgh3

Feature Type

protein coding gene
IDs

MGI:1328354
NCBI Gene: 13384
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:101890478-101919287 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.48 cM
Mapping Data

3 experiments

SNPs within 2kb

978 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328354	protein coding gene	Chr11:101890478-101925854 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019217	protein coding gene	Chr11:104941701-104971188 (-)
A/J	MGP_AJ_G0019185	protein coding gene	Chr11:100510322-100539088 (-)
AKR/J	MGP_AKRJ_G0019154	protein coding gene	Chr11:103624689-103654672 (-)
BALB/cJ	MGP_BALBcJ_G0019159	protein coding gene	Chr11:100995017-101024585 (-)
C3H/HeJ	MGP_C3HHeJ_G0018968	protein coding gene	Chr11:103828941-103857516 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019608	protein coding gene	Chr11:108213246-108243355 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017234	protein coding gene	Chr11:97935051-97963736 (-)
CAST/EiJ	MGP_CASTEiJ_G0018522	protein coding gene	Chr11:104794415-104824541 (-)
CBA/J	MGP_CBAJ_G0018937	protein coding gene	Chr11:112680302-112711456 (-)
DBA/2J	MGP_DBA2J_G0019049	protein coding gene	Chr11:100036268-100065698 (-)
FVB/NJ	MGP_FVBNJ_G0019039	protein coding gene	Chr11:99562030-99592223 (-)
LP/J	MGP_LPJ_G0019118	protein coding gene	Chr11:105457710-105489998 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019070	protein coding gene	Chr11:112208152-112242739 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019646	protein coding gene	Chr11:103986858-104015483 (-)
PWK/PhJ	MGP_PWKPhJ_G0018285	protein coding gene	Chr11:101096309-101127289 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018077	protein coding gene	Chr11:103734088-103770998 (-)
WSB/EiJ	MGP_WSBEiJ_G0018571	protein coding gene	Chr11:103970038-103998563 (-)

Human Ortholog

MPP3, MAGUK p55 scaffold protein 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPP3, MAGUK p55 scaffold protein 3
Synonyms

DLG3
Links

HGNC:7221

NCBI Gene ID: 4356

neXtProt AC: NX_Q13368

UniProt: Q13368
Chr Location

17q21.31; chr17:43800799-43833170 (-) GRCh38

MGI Vertebrate Homology

Mpp3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MPP3
Gene Tree

Mpp3

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Phenotype Summary

15 phenotypes from 2 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

4
Targeted

6
Genomic Mutations

1 involving Mpp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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All GO Annotations

11
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

933
Tissues

43
cDNA Data

21
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

64
RefSeq

19
UniProt

3
CCDS

CCDS36338.1

Ensembl

ENSMUSG00000052373 (Evidence)
NCBI Gene

13384

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052373	Ensembl Gene Model \| MGI Sequence Detail	28810	C57BL/6J	± kb
transcript	ENSMUST00000062801	Ensembl \| MGI Sequence Detail	2848	Not Applicable
polypeptide	ENSMUSP00000055469	Ensembl \| MGI Sequence Detail	585	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029125 MAGUK p55 subfamily member 3

(term hierarchy)
InterPro Domains

IPR020590 Guanylate kinase, conserved site

IPR008144 Guanylate kinase-like domain

IPR008145 Guanylate kinase/L-type calcium channel beta subunit

IPR004172 L27 domain

IPR014775 L27 domain, C-terminal

IPR036892 L27 domain superfamily

IPR050716 Membrane-associated guanylate kinase

IPR035604 MPP3, SH3 domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

O88910 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 23

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 18
Earliest

J:48003 Lin L, et al., cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):211-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mpp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110986	Chr11:101917750-101917788 (-)	1,518 bp
Tssr110985	Chr11:101917704-101917728 (-)	1,571 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24