Myom2 MGI Mouse Gene Detail - MGI:1328358

Symbol

Myom2
Name

myomesin 2

Feature Type

protein coding gene
IDs

MGI:1328358
NCBI Gene: 17930
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr8:15107653-15183410 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 7.63 cM
Mapping Data

1 experiment

SNPs within 2kb

2513 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328358	protein coding gene	Chr8:15107653-15183541 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033401	protein coding gene	Chr8:12490963-12569280 (+)
A/J	MGP_AJ_G0033382	protein coding gene	Chr8:12053718-12127919 (+)
AKR/J	MGP_AKRJ_G0033312	protein coding gene	Chr8:12351322-12422693 (+)
BALB/cJ	MGP_BALBcJ_G0033382	protein coding gene	Chr8:12126413-12201029 (+)
C3H/HeJ	MGP_C3HHeJ_G0033095	protein coding gene	Chr8:12578964-12649648 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033894	protein coding gene	Chr8:12870040-12942259 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030860	protein coding gene	Chr8:11454057-11524384 (+)
CAST/EiJ	MGP_CASTEiJ_G0032417	protein coding gene	Chr8:12395541-12465377 (+)
CBA/J	MGP_CBAJ_G0033068	protein coding gene	Chr8:13410460-13484149 (+)
DBA/2J	MGP_DBA2J_G0033222	protein coding gene	Chr8:11963320-12037925 (+)
FVB/NJ	MGP_FVBNJ_G0033170	protein coding gene	Chr8:11998270-12069540 (+)
LP/J	MGP_LPJ_G0033315	protein coding gene	Chr8:12469194-12557892 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033207	protein coding gene	Chr8:13627904-13706343 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033911	protein coding gene	Chr8:12439319-12515741 (+)
PWK/PhJ	MGP_PWKPhJ_G0032130	protein coding gene	Chr8:12030848-12103567 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031971	protein coding gene	Chr8:12329769-12416256 (+)
WSB/EiJ	MGP_WSBEiJ_G0032533	protein coding gene	Chr8:12473402-12543920 (+)

Human Ortholog

MYOM2, myomesin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYOM2, myomesin 2
Synonyms

TTNAP
Links

HGNC:7614

NCBI Gene ID: 9172

neXtProt AC: NX_P54296

UniProt: P54296
Chr Location

8p23.3; chr8:2045046-2165552 (+) GRCh38

MGI Vertebrate Homology

Myom2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYOM2
Gene Tree

Myom2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

98 strains or lines available

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

32
cDNA Data

15
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myom2

ZFIN myom2a

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All Sequences

60
RefSeq

20
UniProt

3
CCDS

CCDS22123.1

Ensembl

ENSMUSG00000031461 (Evidence)
NCBI Gene

17930

			Length	Strain/Species	Flank
genomic	17930	NCBI Gene Model \| MGI Sequence Detail	75758	C57BL/6J	± kb
transcript	NM_001414185	RefSeq \| MGI Sequence Detail	5658	C57BL/6
polypeptide	NP_001401119	RefSeq \| MGI Sequence Detail	1516	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR050964 Striated Muscle Structural and Regulatory Protein
GlyGen

Q14BI5 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

Genomic 4

cDNA 15

Primer pair 4

Microarray probesets 6

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MGI:2142771

Summaries

All 40

Developmental Gene Expression 11

Gene Ontology 6

Phenotypes 7
Earliest

J:32589 Schiaffino S, et al., Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996 Apr;76(2):371-423
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myom2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76497	Chr8:15107149-15107160 (+)	-498 bp
Tssr76498	Chr8:15107334-15107344 (+)	-314 bp
Tssr76499	Chr8:15107646-15107660 (+)	0 bp
Tssr76500	Chr8:15107667-15107691 (+)	26 bp
Tssr76501	Chr8:15108970-15108974 (+)	1,319 bp
Tssr76502	Chr8:15108999-15109010 (+)	1,352 bp
Tssr76503	Chr8:15109058-15109081 (+)	1,417 bp
Tssr76504	Chr8:15109083-15109090 (+)	1,434 bp
Tssr76505	Chr8:15110152-15110218 (+)	2,532 bp
Tssr76506	Chr8:15110282-15110301 (+)	2,639 bp
Tssr76507	Chr8:15110314-15110346 (+)	2,677 bp
Tssr76508	Chr8:15114820-15114830 (+)	7,172 bp
Tssr76509	Chr8:15127718-15127725 (+)	20,069 bp
Tssr76510	Chr8:15136117-15136125 (+)	28,468 bp
Tssr76511	Chr8:15136239-15136246 (+)	28,590 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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