Arid3a MGI Mouse Gene Detail - MGI:1328360 - AT-rich interaction domain 3A

Symbol

Arid3a
Name

AT-rich interaction domain 3A
Synonyms

Bright, Dri1

Feature Type

protein coding gene
IDs

MGI:1328360
NCBI Gene: 13496
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:79762877-79790852 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

523 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328360	protein coding gene	Chr10:79762877-79790852 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017472	protein coding gene	Chr10:80492259-80523534 (+)
A/J	MGP_AJ_G0017450	protein coding gene	Chr10:77682875-77711454 (+)
AKR/J	MGP_AKRJ_G0017411	protein coding gene	Chr10:79800614-79828431 (+)
BALB/cJ	MGP_BALBcJ_G0017412	protein coding gene	Chr10:77909032-77937786 (+)
C3H/HeJ	MGP_C3HHeJ_G0017235	protein coding gene	Chr10:79904400-79933699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017866	protein coding gene	Chr10:83271360-83303220 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015554	protein coding gene	Chr10:73908361-73936876 (+)
CAST/EiJ	MGP_CASTEiJ_G0016802	protein coding gene	Chr10:80094116-80126779 (+)
CBA/J	MGP_CBAJ_G0017207	protein coding gene	Chr10:86494178-86528622 (+)
DBA/2J	MGP_DBA2J_G0017313	protein coding gene	Chr10:76897766-76927407 (+)
FVB/NJ	MGP_FVBNJ_G0017307	protein coding gene	Chr10:76075795-76106135 (+)
LP/J	MGP_LPJ_G0017384	protein coding gene	Chr10:80969367-80999794 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017333	protein coding gene	Chr10:88465710-88496457 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017907	protein coding gene	Chr10:79788180-79815996 (+)
PWK/PhJ	MGP_PWKPhJ_G0016583	protein coding gene	Chr10:76763480-76792404 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016372	protein coding gene	Chr10:78758531-78787763 (+)
WSB/EiJ	MGP_WSBEiJ_G0016862	protein coding gene	Chr10:79810603-79839393 (+)

Human Ortholog

ARID3A, AT-rich interaction domain 3A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARID3A, AT-rich interaction domain 3A
Synonyms

BRIGHT, DRIL1, DRIL3, E2FBP1
Links

HGNC:3031

NCBI Gene ID: 1820

neXtProt AC: NX_Q99856

UniProt: Q99856
Chr Location

19p13.3; chr19:925732-975939 (+) GRCh38

MGI Vertebrate Homology

Arid3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARID3A
Gene Tree

Arid3a

less

Phenotype Summary

41 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Arid3a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality between E11.5 and E13.5 due to impaired erythropoiesis.

less

All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

874
Tissues

125
cDNA Data

31
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arid3a

less

All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS23999.1, CCDS78851.1

Ensembl

ENSMUSG00000019564 (Evidence)
NCBI Gene

13496

			Length	Strain/Species	Flank
genomic	13496	NCBI Gene Model \| MGI Sequence Detail	27976	C57BL/6J	± kb
transcript	NM_007880	RefSeq \| MGI Sequence Detail	5361	C57BL/6
polypeptide	Q62431	UniProt \| EBI \| MGI Sequence Detail	601	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000004265 AT-rich interactive domain-containing protein 3A

(term hierarchy)
InterPro Domains

IPR001606 ARID DNA-binding domain

IPR036431 ARID DNA-binding domain superfamily

IPR045147 AT-rich interactive domain-containing protein 3

IPR023334 REKLES domain
GlyGen

Q62431 4 sites, 1 O-linked glycan (4 sites)

less

All nucleic 34

Genomic 1

cDNA 31

Primer pair 2

Microarray probesets 3

Summaries

All 67

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056

TSS for Arid3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94432	Chr10:79762873-79762922 (+)	21 bp
Tssr94433	Chr10:79763164-79763204 (+)	307 bp
Tssr94434	Chr10:79763209-79763218 (+)	337 bp
Tssr94435	Chr10:79766228-79766243 (+)	3,359 bp
Tssr94436	Chr10:79766253-79766262 (+)	3,381 bp
Tssr94437	Chr10:79782107-79782130 (+)	19,242 bp
Tssr94438	Chr10:79784809-79784837 (+)	21,946 bp
Tssr94439	Chr10:79788133-79788150 (+)	25,265 bp
Tssr94440	Chr10:79788240-79788247 (+)	25,367 bp
Tssr94441	Chr10:79790235-79790279 (+)	27,380 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24