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Slfn5 Gene Detail
Summary
  • Symbol
    Slfn5
  • Name
    schlafen 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329004
    NCBI Gene: 327978
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82842175-82855666 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329004
 protein coding gene Chr11:82842175-82855681 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018836
 protein coding gene Chr11:84240511-84252105 (+)
A/J MGP_AJ_G0018803
 protein coding gene Chr11:81001906-81013603 (+)
AKR/J MGP_AKRJ_G0018773
 protein coding gene Chr11:83440488-83452075 (+)
BALB/cJ MGP_BALBcJ_G0018776
 protein coding gene Chr11:81408470-81420595 (+)
C3H/HeJ MGP_C3HHeJ_G0018590
 protein coding gene Chr11:83463929-83475500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019228
 protein coding gene Chr11:86762136-86775241 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016862
 protein coding gene Chr11:77960918-77974494 (+)
CAST/EiJ MGP_CASTEiJ_G0018145
 protein coding gene Chr11:84050729-84062349 (+)
CBA/J MGP_CBAJ_G0018561
 protein coding gene Chr11:90515143-90526733 (+)
DBA/2J MGP_DBA2J_G0018669
 protein coding gene Chr11:80576927-80588869 (+)
FVB/NJ MGP_FVBNJ_G0018658
 protein coding gene Chr11:80100855-80112429 (+)
LP/J MGP_LPJ_G0018739
 protein coding gene Chr11:84753416-84765007 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018685
 protein coding gene Chr11:90711632-90724414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019268
 protein coding gene Chr11:83688890-83702016 (+)
PWK/PhJ MGP_PWKPhJ_G0017915
 protein coding gene Chr11:81401153-81413002 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017706
 protein coding gene Chr11:83323499-83335026 (+)
WSB/EiJ MGP_WSBEiJ_G0018197
 protein coding gene Chr11:83577940-83590392 (+)



Homology
more
  • Human Ortholog
    SLFN5, schlafen family member 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLFN5, schlafen family member 5
  • Links
    NCBI Gene ID: 162394
    neXtProt AC: NX_Q08AF3
    UniProt: Q08AF3

  • Chr Location
    17q12; chr17:35243071-35273655 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Mice homozygous for a null allele show normal MOG-induced experimental autoimmune encephalitis development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    11
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054404 Ensembl Gene Model | MGI Sequence Detail 13492 C57BL/6J ±  kb
transcript ENSMUST00000067443 Ensembl | MGI Sequence Detail 5979 Not Applicable  
polypeptide ENSMUSP00000064819 Ensembl | MGI Sequence Detail 884 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2671063
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory