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Slc22a5 Gene Detail
Summary
  • Symbol
    Slc22a5
  • Name
    solute carrier family 22 (organic cation transporter), member 5
  • Synonyms
    Lstpl, Octn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329012
    NCBI Gene: 20520
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53755368-53782486 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.02 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    768 from dbSNP Build 142
  • Strain Annotations
    12
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329012
 protein coding gene Chr11:53755368-53782609 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018307
 protein coding gene Chr11:53294614-53325307 (-)
A/J MGP_AJ_G0018276
 protein coding gene Chr11:51288617-51316620 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0018247
 protein coding gene Chr11:51640997-51665247 (-)
C3H/HeJ MGP_C3HHeJ_G0018058
 protein coding gene Chr11:52936140-52969672 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018699
 protein coding gene Chr11:54899150-54934409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016349
 protein coding gene Chr11:48799746-48828201 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0018033
 protein coding gene Chr11:57507762-57557521 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0018217
 protein coding gene Chr11:53752425-53774540 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018159
 protein coding gene Chr11:58792207-58811394 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018741
 protein coding gene Chr11:53089463-53104037 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017670
 protein coding gene Chr11:52627838-52665694 (-)



Homology
more
  • Human Ortholog
    SLC22A5, solute carrier family 22 member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A5, solute carrier family 22 member 5
  • Synonyms
    CDSP, OCTN2
  • Links
    NCBI Gene ID: 6584
    neXtProt AC: NX_O76082
    UniProt: O76082

  • Chr Location
    5q31.1; chr5:132369710-132395613 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc22a5 mouse models; 4 with human SLC22A5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous missense mutation exhibit systemic carnitine deficiency, cardiac hypertrophy, impaired Na-dependent carnitine transport, fatty liver, hypoglycemia, high postnatal mortality, and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    27
  • cDNA Data
    63
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018900 Ensembl Gene Model | MGI Sequence Detail 27119 C57BL/6J ±  kb
    transcript ENSMUST00000019044 Ensembl | MGI Sequence Detail 3062 Not Applicable  
    polypeptide ENSMUSP00000019044 Ensembl | MGI Sequence Detail 557 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000014992 organic cation/carnitine transporter 2
      (term hierarchy)
    • InterPro Domains
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR004749 Organic cation transport protein/SVOP
      IPR045915 Solute carrier family 22 members 4/5
      IPR005829 Sugar transporter, conserved site
    • GlyGen
      Q9Z0E8 3 sites, 4 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 6
      cDNA 63
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11546, MGI:894333, MGI:96652
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 8
      Diseases 8
      Gene Ontology 26
      Phenotypes 55
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory