Cct6b MGI Mouse Gene Detail - MGI:1329013 - chaperonin containing TCP1 subunit 6B

Symbol

Cct6b
Name

chaperonin containing TCP1 subunit 6B
Synonyms

Cctz-2, CCTzeta-2

Feature Type

protein coding gene
IDs

MGI:1329013
NCBI Gene: 12467
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:82610076-82655147 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.18 cM, cytoband B5
Mapping Data

1 experiment

SNPs within 2kb

1442 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1329013	protein coding gene	Chr11:82603938-82655154 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018828	protein coding gene	Chr11:83986969-84036597 (-)
A/J	MGP_AJ_G0018795	protein coding gene	Chr11:80762558-80808869 (-)
AKR/J	MGP_AKRJ_G0018765	protein coding gene	Chr11:83189343-83233969 (-)
BALB/cJ	MGP_BALBcJ_G0018768	protein coding gene	Chr11:81165253-81210582 (-)
C3H/HeJ	MGP_C3HHeJ_G0018582	protein coding gene	Chr11:83222142-83268818 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019220	protein coding gene	Chr11:86506322-86558502 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016854	protein coding gene	Chr11:77721235-77765963 (-)
CAST/EiJ	MGP_CASTEiJ_G0018137	protein coding gene	Chr11:83797761-83851602 (-)
CBA/J	MGP_CBAJ_G0018553	protein coding gene	Chr11:90258024-90304608 (-)
DBA/2J	MGP_DBA2J_G0018661	protein coding gene	Chr11:80337692-80384986 (-)
FVB/NJ	MGP_FVBNJ_G0018650	protein coding gene	Chr11:79865447-79911750 (-)
LP/J	MGP_LPJ_G0018731	protein coding gene	Chr11:84508311-84555540 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018677	protein coding gene	Chr11:90462664-90512524 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019260	protein coding gene	Chr11:83443216-83491867 (-)
PWK/PhJ	MGP_PWKPhJ_G0017907	protein coding gene	Chr11:81157632-81205245 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017698	protein coding gene	Chr11:83057572-83107615 (-)
WSB/EiJ	MGP_WSBEiJ_G0018189	protein coding gene	Chr11:83332493-83380328 (-)

Human Ortholog

CCT6B, chaperonin containing TCP1 subunit 6B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCT6B, chaperonin containing TCP1 subunit 6B
Synonyms

Cctz2, CCTZ-2, CCT-zeta-2, TCP-1-zeta-2, TSA303
Links

HGNC:1621

NCBI Gene ID: 10693

neXtProt AC: NX_Q92526

UniProt: Q92526
Chr Location

17q12; chr17:34927859-34981078 (-) GRCh38

MGI Vertebrate Homology

Cct6b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCT6B
Gene Tree

Cct6b

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Phenotype Summary

4 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

7
Targeted

1
Genomic Mutations

2 involving Cct6b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for null mutations in this gene are viable and show normal male fertility. Interestingly, males homozygous for one null allele remain fertile but show decreased sperm progressive motility and teratospermia characterized by sperm neck bending and cytoplasmic redundancy.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

11
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

13
UniProt

4
CCDS

CCDS25145.1, CCDS70265.1

Ensembl

ENSMUSG00000020698 (Evidence)
NCBI Gene

12467

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020698	Ensembl Gene Model \| MGI Sequence Detail	45072	C57BL/6J	± kb
transcript	ENSMUST00000021040	Ensembl \| MGI Sequence Detail	1787	Not Applicable
polypeptide	ENSMUSP00000021040	Ensembl \| MGI Sequence Detail	531	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005155 T-complex protein 1 subunit zeta-2

(term hierarchy)
InterPro Domains

IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)

IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family

IPR002194 Chaperonin TCP-1, conserved site

IPR027409 GroEL-like apical domain superfamily

IPR027413 GroEL-like equatorial domain superfamily

IPR012722 T-complex protein 1, zeta subunit

IPR053374 TCP-1 chaperonin-containing T-complex

IPR027410 TCP-1-like chaperonin intermediate domain superfamily

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:323102 Cazin C, et al., Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B. Cells. 2021 Dec 30;11(1)

TSS for Cct6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109577	Chr11:82655598-82655612 (-)	-458 bp
Tssr109576	Chr11:82655129-82655155 (-)	5 bp
Tssr109575	Chr11:82655113-82655123 (-)	29 bp
Tssr109574	Chr11:82655100-82655103 (-)	45 bp
Tssr109573	Chr11:82655067-82655099 (-)	64 bp
Tssr109572	Chr11:82655053-82655066 (-)	87 bp
Tssr109571	Chr11:82654700-82654711 (-)	441 bp
Tssr109570	Chr11:82642320-82642362 (-)	12,806 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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