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Stam Gene Detail
Summary
  • Symbol
    Stam
  • Name
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
  • Synonyms
    STAM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329014
    NCBI Gene: 20844
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:14078912-14152351 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 10.36 cM, cytoband A2-B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329014
 protein coding gene Chr2:14078909-14154445 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025360
 protein coding gene Chr2:11580745-11655747 (+)
A/J MGP_AJ_G0025337
 protein coding gene Chr2:11151604-11227709 (+)
AKR/J MGP_AKRJ_G0025306
 protein coding gene Chr2:11476649-11550670 (+)
BALB/cJ MGP_BALBcJ_G0025333
 protein coding gene Chr2:11145118-11214642 (+)
C3H/HeJ MGP_C3HHeJ_G0025093
 protein coding gene Chr2:11432629-11496403 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025775
 protein coding gene Chr2:11903871-11969784 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023190
 protein coding gene Chr2:10716133-10775189 (+)
CAST/EiJ MGP_CASTEiJ_G0024556
 protein coding gene Chr2:11410191-11465196 (+)
CBA/J MGP_CBAJ_G0025072
 protein coding gene Chr2:12409988-12479507 (+)
DBA/2J MGP_DBA2J_G0025204
 protein coding gene Chr2:11045623-11116092 (+)
FVB/NJ MGP_FVBNJ_G0025166
 protein coding gene Chr2:10946042-11019214 (+)
LP/J MGP_LPJ_G0025290
 protein coding gene Chr2:11510850-11568593 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025198
 protein coding gene Chr2:12261786-12321430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025833
 protein coding gene Chr2:11383610-11453852 (+)
PWK/PhJ MGP_PWKPhJ_G0024307
 protein coding gene Chr2:10932617-10989103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024107
 protein coding gene Chr2:11451125-11511424 (+)
WSB/EiJ MGP_WSBEiJ_G0024626
 protein coding gene Chr2:11510060-11580733 (+)



Homology
more
  • Human Ortholog
    STAM, signal transducing adaptor molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAM, signal transducing adaptor molecule
  • Synonyms
    STAM-1, STAM1
  • Links
    NCBI Gene ID: 8027
    neXtProt AC: NX_Q92783
    UniProt: Q92783

  • Chr Location
    10p12.33; chr10:17644151-17716824 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit progressive growth retardation, priapism, male infertility, degeneration of hippocapal CA3 pyramidal neurons and premature death, but exhibit normal lymphocyte development, proliferation and responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    10
  • cDNA Data
    88
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20844 NCBI Gene Model | MGI Sequence Detail 73440 C57BL/6J ±  kb
    transcript NM_001421097 RefSeq | MGI Sequence Detail 4127 C57BL/6  
    polypeptide P70297 UniProt | EBI | MGI Sequence Detail 548 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 89
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:51739 Takeshita T, et al., Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. Biochem Biophys Res Commun. 1996 Aug 23;225(3):1035-9
    • Latest
      J:235672 Nam H, et al., Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons. Development. 2016 Jul 1;143(13):2334-43
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory