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Nfatc2ip Gene Detail
Summary
  • Symbol
    Nfatc2ip
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
  • Synonyms
    D7Ertd304e, NIP45
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329015
    NCBI Gene: 18020
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125982026-125995909 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.01 cM, cytoband F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329015
 protein coding gene Chr7:125982025-125995909 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032977
 protein coding gene Chr7:130645482-130663827 (-)
A/J MGP_AJ_G0032960
 protein coding gene Chr7:127199571-127214646 (-)
AKR/J MGP_AKRJ_G0032892
 protein coding gene Chr7:130418424-130432227 (-)
BALB/cJ MGP_BALBcJ_G0032965
 protein coding gene Chr7:126858501-126872674 (-)
C3H/HeJ MGP_C3HHeJ_G0032675
 protein coding gene Chr7:130342483-130356964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033471
 protein coding gene Chr7:135734579-135753599 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030443
 protein coding gene Chr7:128393987-128407977 (-)
CAST/EiJ MGP_CASTEiJ_G0032003
 protein coding gene Chr7:122128785-122142094 (-)
CBA/J MGP_CBAJ_G0032648
 protein coding gene Chr7:140309907-140326999 (-)
DBA/2J MGP_DBA2J_G0032800
 protein coding gene Chr7:125174700-125188533 (-)
FVB/NJ MGP_FVBNJ_G0032753
 protein coding gene Chr7:125022506-125037590 (-)
LP/J MGP_LPJ_G0032894
 protein coding gene Chr7:132111068-132131989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032785
 protein coding gene Chr7:141504861-141520933 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033491
 protein coding gene Chr7:129435244-129451664 (-)
PWK/PhJ MGP_PWKPhJ_G0031711
 protein coding gene Chr7:118162185-118177133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031557
 protein coding gene Chr7:116247036-116264140 (-)
WSB/EiJ MGP_WSBEiJ_G0032116
 protein coding gene Chr7:130396594-130411347 (-)



Homology
more
  • Human Ortholog
    NFATC2IP, nuclear factor of activated T cells 2 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFATC2IP, nuclear factor of activated T cells 2 interacting protein
  • Synonyms
    ESC2, NIP45, RAD60
  • Links
    NCBI Gene ID: 84901
    neXtProt AC: NX_Q8NCF5
    UniProt: Q8NCF5

  • Chr Location
    16p11.2; chr16:28950807-28967092 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display profound defects in the expression of NFAT-regulated cytokine genes and defects in the efficient handling of parasites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    7
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030722 Ensembl Gene Model | MGI Sequence Detail 13884 C57BL/6J ±  kb
    transcript ENSMUST00000075671 Ensembl | MGI Sequence Detail 3388 Not Applicable  
    polypeptide ENSMUSP00000075094 Ensembl | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1098707
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:51755 Hodge MR, et al., NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science. 1996 Dec 13;274(5294):1903-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory