Msh5 MGI Mouse Gene Detail - MGI:1329021

Symbol

Msh5
Name

mutS homolog 5
Synonyms

G7, Mut5

Feature Type

protein coding gene
IDs

MGI:1329021
NCBI Gene: 17687
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:35247581-35265721 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.57 cM
Mapping Data

3 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1329021	protein coding gene	Chr17:35247581-35267842 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023608	protein coding gene	Chr17:35161204-35183095 (-)
A/J	MGP_AJ_G0023568	protein coding gene	Chr17:34002760-34020743 (-)
AKR/J	MGP_AKRJ_G0023536	protein coding gene	Chr17:34474408-34491738 (-)
BALB/cJ	MGP_BALBcJ_G0023574	protein coding gene	Chr17:34133085-34152180 (-)
C3H/HeJ	MGP_C3HHeJ_G0023335	protein coding gene	Chr17:34868610-34887260 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024013	protein coding gene	Chr17:36503804-36522858 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021494	protein coding gene	Chr17:31769284-31787384 (-)
CAST/EiJ	MGP_CASTEiJ_G0022832	protein coding gene	Chr17:34870896-34890650 (-)
CBA/J	MGP_CBAJ_G0023313	protein coding gene	Chr17:38013013-38030671 (-)
DBA/2J	MGP_DBA2J_G0023441	protein coding gene	Chr17:33322544-33341080 (-)
FVB/NJ	MGP_FVBNJ_G0023408	protein coding gene	Chr17:33157760-33176620 (-)
LP/J	MGP_LPJ_G0023518	protein coding gene	Chr17:35489901-35509524 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023430	protein coding gene	Chr17:36944928-36964915 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024058	protein coding gene	Chr17:34697017-34714416 (-)
PWK/PhJ	MGP_PWKPhJ_G0022579	protein coding gene	Chr17:32153601-32173743 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022399	protein coding gene	Chr17:32706089-32726579 (-)
WSB/EiJ	MGP_WSBEiJ_G0022895	protein coding gene	Chr17:34810019-34829406 (-)

Human Ortholog

MSH5, mutS homolog 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MSH5, mutS homolog 5
Synonyms

G7, MUTSH5, NG23, POF13, SPGF74
Links

HGNC:7328

NCBI Gene ID: 4439

neXtProt AC: NX_O43196

UniProt: O43196
Chr Location

6p21.33; chr6:31739677-31762676 (+) GRCh38

MGI Vertebrate Homology

Msh5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MSH5
Gene Tree

Msh5

Diseases

1 with Msh5 mouse models; 3 with human MSH5 associations

Human Disease

Mouse Models

primary ovarian insufficiency 13

IDs

View 1 model

lung non-small cell carcinoma

IDs

spermatogenic failure 74

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

25 phenotypes from 4 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

3
Gene trapped

7
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit disrupted chromosome pairing in meiosis I resulting in cell death and sterility. In males, testes size is reduced, and in females, there is a total loss of ovarian structure.

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

12
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase msh5

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All Sequences

114
RefSeq

52
UniProt

9
CCDS

CCDS28674.1

Ensembl

ENSMUSG00000007035 (Evidence)
NCBI Gene

17687

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007035	Ensembl Gene Model \| MGI Sequence Detail	18141	C57BL/6J	± kb
transcript	ENSMUST00000007250	Ensembl \| MGI Sequence Detail	2886	Not Applicable
polypeptide	ENSMUSP00000007250	Ensembl \| MGI Sequence Detail	833	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010669 MutS protein homolog 5

(term hierarchy)
InterPro Domains

IPR011184 DNA mismatch repair Msh2-type

IPR045076 DNA mismatch repair MutS family

IPR007696 DNA mismatch repair protein MutS, core

IPR036187 DNA mismatch repair protein MutS, core domain superfamily

IPR000432 DNA mismatch repair protein MutS, C-terminal

IPR017261 DNA mismatch repair protein MutS/MSH

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 23

Genomic 6

cDNA 15

Primer pair 2

Microarray probesets 3

Summaries

All 57

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 26
Earliest

J:51921 Edelmann W, et al., Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet. 1999 Jan;21(1):123-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Msh5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147730	Chr17:35265713-35265739 (-)	-5 bp
Tssr147729	Chr17:35265515-35265535 (-)	196 bp
Tssr147728	Chr17:35265477-35265490 (-)	237 bp
Tssr147727	Chr17:35265424-35265435 (-)	291 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24