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Clcnka Gene Detail
Summary
  • Symbol
    Clcnka
  • Name
    chloride channel, voltage-sensitive Ka
  • Synonyms
    CLC-K1, Clcnk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329026
    NCBI Gene: 12733
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141111922-141126017 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 73.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    677 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329026
 protein coding gene Chr4:141111921-141126035 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029045
 protein coding gene Chr4:144439727-144455070 (-)
A/J MGP_AJ_G0029004
 protein coding gene Chr4:138151924-138166062 (-)
AKR/J MGP_AKRJ_G0028956
 protein coding gene Chr4:142137881-142151869 (-)
BALB/cJ MGP_BALBcJ_G0029028
 protein coding gene Chr4:138845842-138860595 (-)
C3H/HeJ MGP_C3HHeJ_G0028742
 protein coding gene Chr4:142517521-142531609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029469
 protein coding gene Chr4:149467605-149481660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026740
 protein coding gene Chr4:131065623-131079655 (-)
CAST/EiJ MGP_CASTEiJ_G0028174
 protein coding gene Chr4:140785741-140801282 (-)
CBA/J MGP_CBAJ_G0028706
 protein coding gene Chr4:153819295-153837279 (-)
DBA/2J MGP_DBA2J_G0028856
 protein coding gene Chr4:138556366-138570857 (-)
FVB/NJ MGP_FVBNJ_G0028823
 protein coding gene Chr4:137663703-137678357 (-)
LP/J MGP_LPJ_G0028955
 protein coding gene Chr4:144455155-144470387 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028849
 protein coding gene Chr4:157639643-157657208 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029507
 protein coding gene Chr4:142669260-142693029 (-)
PWK/PhJ MGP_PWKPhJ_G0027895
 protein coding gene Chr4:135441702-135456029 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027720
 protein coding gene Chr4:138478483-138498773 (-)
WSB/EiJ MGP_WSBEiJ_G0028252
 protein coding gene Chr4:142952151-142965995 (-)



Homology
more
  • Human Ortholog
    CLCNKA, chloride voltage-gated channel Ka
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCNKA, chloride voltage-gated channel Ka
  • Synonyms
    ClC-K1, CLCK1, hClC-Ka
  • Links
    NCBI Gene ID: 1187
    neXtProt AC: NX_P51800
    UniProt: P51800

  • Chr Location
    1p36.13; chr1:16018875-16034050 (+)  GRCh38
  • Human Ortholog
    CLCNKB, chloride voltage-gated channel Kb
  • Synonyms
    ClC-K2, ClC-Kb, CLCKB
  • Links
    NCBI Gene ID: 1188
    neXtProt AC: NX_P51801
    UniProt: P51801

  • Chr Location
    1p36.13; chr1:16040252-16057326 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Clcnka mouse models; 5 with human CLCNKA,CLCNKB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased urine volume and decreased urine osmolarity. Mice homozygous for an ENU-induced allele exhibit increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    53
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12733 NCBI Gene Model | MGI Sequence Detail 14096 C57BL/6J ±  kb
    transcript NM_024412 RefSeq | MGI Sequence Detail 2409 C57BL/6  
    polypeptide Q9WUB7 UniProt | EBI | MGI Sequence Detail 687 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140644
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:51917 Matsumura Y, et al., Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel [see comments]. Nat Genet. 1999 Jan;21(1):95-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory