Agxt MGI Mouse Gene Detail - MGI:1329033 - alanine-glyoxylate aminotransferase

Symbol

Agxt
Name

alanine-glyoxylate aminotransferase
Synonyms

Agt1, Agxt1

Feature Type

protein coding gene
IDs

MGI:1329033
NCBI Gene: 11611
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:93062962-93073143 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.00 cM
Mapping Data

1 experiment

SNPs within 2kb

361 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1329033	protein coding gene	Chr1:93062962-93073143 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016334	protein coding gene	Chr1:94745069-94755247 (+)
A/J	MGP_AJ_G0016315	protein coding gene	Chr1:91350466-91360643 (+)
AKR/J	MGP_AKRJ_G0016276	protein coding gene	Chr1:94046631-94056808 (+)
BALB/cJ	MGP_BALBcJ_G0016271	protein coding gene	Chr1:91529424-91539601 (+)
C3H/HeJ	MGP_C3HHeJ_G0016100	protein coding gene	Chr1:94303972-94314157 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016730	protein coding gene	Chr1:98341942-98351936 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014448	protein coding gene	Chr1:85608963-85619188 (+)
CAST/EiJ	MGP_CASTEiJ_G0015683	protein coding gene	Chr1:93631518-93641615 (+)
CBA/J	MGP_CBAJ_G0016074	protein coding gene	Chr1:101539218-101549482 (+)
DBA/2J	MGP_DBA2J_G0016179	protein coding gene	Chr1:90548759-90558963 (+)
FVB/NJ	MGP_FVBNJ_G0016178	protein coding gene	Chr1:89620187-89630359 (+)
LP/J	MGP_LPJ_G0016250	protein coding gene	Chr1:95926519-95936705 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016203	protein coding gene	Chr1:104656961-104667139 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016769	protein coding gene	Chr1:94068700-94079363 (+)
PWK/PhJ	MGP_PWKPhJ_G0015468	protein coding gene	Chr1:89984485-89994598 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015252	protein coding gene	Chr1:93016990-93027143 (+)
WSB/EiJ	MGP_WSBEiJ_G0015743	protein coding gene	Chr1:93882348-93892511 (+)

Human Ortholog

AGXT, alanine--glyoxylate aminotransferase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGXT, alanine--glyoxylate aminotransferase
Synonyms

AGT, AGT1, AGXT1, PH1, Ser-PyrAT, SPAT, SPT, TLH6
Links

HGNC:341

NCBI Gene ID: 189

neXtProt AC: NX_P21549

UniProt: P21549
Chr Location

2q37.3; chr2:240868824-240880502 (+) GRCh38

MGI Vertebrate Homology

Agxt stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AGXT
Protein SuperFamily

SPT
Gene Tree

Agxt

Diseases

1 with Agxt mouse models; 1 with human AGXT associations

Human Disease

Mouse Models

primary hyperoxaluria type 1

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Agxt
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased urinary oxalate levels and male mice suffer from bladder stones.

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All GO Annotations

55
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

813
Tissues

106
cDNA Data

49
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agxt

ZFIN agxta, agxtb

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS15184.1

Ensembl

ENSMUSG00000026272 (Evidence)
NCBI Gene

11611

			Length	Strain/Species	Flank
genomic	11611	NCBI Gene Model \| MGI Sequence Detail	10182	C57BL/6J	± kb
transcript	NM_001276710	RefSeq \| MGI Sequence Detail	1553	ZRU/MplStud
polypeptide	O35423	UniProt \| EBI \| MGI Sequence Detail	414	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030629 alanine--glyoxylate aminotransferase

(term hierarchy)
PDB

3KGW, 3KGX
EC

2.6.1.44, 2.6.1.51
InterPro Domains

IPR000192 Aminotransferase class V domain

IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain

IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
GlyGen

O35423 1 site, 1 O-linked glycan (1 site)

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All nucleic 52

Genomic 1

cDNA 49

Primer pair 2

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 2

Diseases 2

Gene Ontology 11

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345961 Torella L, et al., Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1. EMBO Mol Med. 2024 Jan;16(1):112-131

TSS for Agxt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8158	Chr1:93062966-93062978 (+)	10 bp
Tssr8159	Chr1:93063032-93063048 (+)	78 bp
Tssr8160	Chr1:93063054-93063061 (+)	96 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24