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Dkk1 Gene Detail
Summary
  • Symbol
    Dkk1
  • Name
    dickkopf WNT signaling pathway inhibitor 1
  • Synonyms
    mdkk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329040
    NCBI Gene: 13380
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:30523276-30526896 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 25.16 cM, cytoband C2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329040
 protein coding gene Chr19:30523263-30527065 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025034
 protein coding gene Chr19:29098135-29101939 (-)
A/J MGP_AJ_G0025011
 protein coding gene Chr19:27635740-27639544 (-)
AKR/J MGP_AKRJ_G0024979
 protein coding gene Chr19:28621145-28624990 (-)
BALB/cJ MGP_BALBcJ_G0025010
 protein coding gene Chr19:27675623-27679424 (-)
C3H/HeJ MGP_C3HHeJ_G0024766
 protein coding gene Chr19:28592011-28595890 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025451
 protein coding gene Chr19:29879704-29883506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022870
 protein coding gene Chr19:27593507-27597382 (-)
CAST/EiJ MGP_CASTEiJ_G0024236
 protein coding gene Chr19:28477471-28481262 (-)
CBA/J MGP_CBAJ_G0024744
 protein coding gene Chr19:31312379-31316169 (-)
DBA/2J MGP_DBA2J_G0024876
 protein coding gene Chr19:27572888-27576677 (-)
FVB/NJ MGP_FVBNJ_G0024838
 protein coding gene Chr19:27394492-27400385 (-)
LP/J MGP_LPJ_G0024961
 protein coding gene Chr19:29105253-29109054 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024865
 protein coding gene Chr19:31212719-31218073 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025506
 protein coding gene Chr19:28636130-28639917 (-)
PWK/PhJ MGP_PWKPhJ_G0023984
 protein coding gene Chr19:27246488-27250309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023788
 protein coding gene Chr19:27956610-27960410 (-)
WSB/EiJ MGP_WSBEiJ_G0024303
 protein coding gene Chr19:28699252-28703046 (-)



Homology
more
  • Human Ortholog
    DKK1, dickkopf WNT signaling pathway inhibitor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DKK1, dickkopf WNT signaling pathway inhibitor 1
  • Synonyms
    DKK-1, SK
  • Links
    NCBI Gene ID: 22943
    neXtProt AC: NX_O94907
    UniProt: O94907

  • Chr Location
    10q21.1; chr10:52314281-52318042 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DKK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 6 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die at birth exhibiting absence of anterior head structures and forelimb malformations ranging from fusion of the distal-most limb elements to the appearance of ectopic preaxial and postaxial digits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1845
  • Tissues
    660
  • cDNA Data
    20
  • Literature Summary
    219
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13380 NCBI Gene Model | MGI Sequence Detail 3621 C57BL/6J ±  kb
    transcript NM_010051 RefSeq | MGI Sequence Detail 2245 C57BL/6  
    polypeptide O54908 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006499 dickkopf-related protein 1
      (term hierarchy)
    • InterPro Domains
      IPR006796 Dickkopf, N-terminal cysteine-rich
      IPR048500 Dickkopf-related protein 1/2/4, C-terminal subdomain 1
      IPR048499 Dickkopf-related protein 1/2/4, C-terminal subdomain 2
      IPR039863 Dickkopf related protein 1-4
      IPR047305 Dickkopf-related protein 1, N-terminal domain
      IPR047304 Dickkopf-related protein 1, second cysteine-rich domain
    • GlyGen
      O54908 2 sites
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 23
      Primer pair 25
      Other 21

      Microarray probesets 3
    References
    more
    • Summaries
      All 347
      Developmental Gene Expression 219
      Gene Ontology 32
      Phenotypes 62
    • Earliest
      J:51745 Glinka A, et al., Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998 Jan 22;391(6665):357-62
    • Latest
      J:355463 Xu N, et al., Wnt Signaling Inhibition Prevents Postnatal Inflammation and Disease Progression in Mouse Congenital Myxomatous Valve Disease. Arterioscler Thromb Vasc Biol. 2024 Jul;44(7):1540-1554
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory