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Rngtt Gene Detail
Summary
  • Symbol
    Rngtt
  • Name
    RNA guanylyltransferase and 5'-phosphatase
  • Synonyms
    mouse capping enzyme
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329041
    NCBI Gene: 24018
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33310311-33502614 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4493 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329041
 protein coding gene Chr4:33310300-33502614 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028123
 protein coding gene Chr4:30826741-31026678 (+)
A/J MGP_AJ_G0028081
 protein coding gene Chr4:29723932-29924433 (+)
AKR/J MGP_AKRJ_G0028044
 protein coding gene Chr4:30507360-30704125 (+)
BALB/cJ MGP_BALBcJ_G0028092
 protein coding gene Chr4:29980857-30173395 (+)
C3H/HeJ MGP_C3HHeJ_G0027821
 protein coding gene Chr4:30797982-30996755 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028534
 protein coding gene Chr4:32030589-32239593 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025875
 protein coding gene Chr4:27882437-28073468 (+)
CAST/EiJ MGP_CASTEiJ_G0027276
 protein coding gene Chr4:30580533-30785303 (+)
CBA/J MGP_CBAJ_G0027793
 protein coding gene Chr4:33095273-33308535 (+)
DBA/2J MGP_DBA2J_G0027937
 protein coding gene Chr4:29722032-29913137 (+)
FVB/NJ MGP_FVBNJ_G0027903
 protein coding gene Chr4:29152282-29345586 (+)
LP/J MGP_LPJ_G0028045
 protein coding gene Chr4:30908857-31122525 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027936
 protein coding gene Chr4:35646773-35856927 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028593
 protein coding gene Chr4:30508568-30709905 (+)
PWK/PhJ MGP_PWKPhJ_G0026995
 protein coding gene Chr4:29729971-29931708 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026824
 protein coding gene Chr4:30391884-30588553 (+)
WSB/EiJ MGP_WSBEiJ_G0027352
 protein coding gene Chr4:30514104-30713554 (+)



Homology
more
  • Human Ortholog
    RNGTT, RNA guanylyltransferase and 5'-phosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNGTT, RNA guanylyltransferase and 5'-phosphatase
  • Synonyms
    CAP1A, hCAP, HCE, HCE1
  • Links
    NCBI Gene ID: 8732
    neXtProt AC: NX_O60942
    UniProt: O60942

  • Chr Location
    6q15; chr6:88609897-88963618 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    17
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028274 Ensembl Gene Model | MGI Sequence Detail 192304 C57BL/6J ±  kb
transcript ENSMUST00000108153 Ensembl | MGI Sequence Detail 4157 Not Applicable  
polypeptide ENSMUSP00000103788 Ensembl | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140461
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:50704 McCracken S, et al., 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II [see comments]. Genes Dev. 1997 Dec 15;11(24):3306-18
  • Latest
    J:324707 Dhandapani L, et al., Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body. J Cell Sci. 2022 Dec 1;135(1):jcs259394
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory