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Cldn3 Gene Detail
Summary
  • Symbol
    Cldn3
  • Name
    claudin 3
  • Synonyms
    Cpetr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329044
    NCBI Gene: 12739
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135015068-135016326 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.93 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329044
 protein coding gene Chr5:135015068-135016330 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030168
 protein coding gene Chr5:139458084-139459342 (+)
A/J MGP_AJ_G0030136
 protein coding gene Chr5:133510218-133511476 (+)
AKR/J MGP_AKRJ_G0030069
 protein coding gene Chr5:137849026-137850284 (+)
BALB/cJ MGP_BALBcJ_G0030146
 protein coding gene Chr5:134864349-134865607 (+)
C3H/HeJ MGP_C3HHeJ_G0029862
 protein coding gene Chr5:138409923-138411181 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030599
 protein coding gene Chr5:144695816-144697074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027822
 protein coding gene Chr5:127808284-127809547 (+)
CAST/EiJ MGP_CASTEiJ_G0029271
 protein coding gene Chr5:137837990-137839248 (+)
CBA/J MGP_CBAJ_G0029832
 protein coding gene Chr5:150345336-150346594 (+)
DBA/2J MGP_DBA2J_G0029983
 protein coding gene Chr5:133405174-133406432 (+)
FVB/NJ MGP_FVBNJ_G0029938
 protein coding gene Chr5:132538699-132539957 (+)
LP/J MGP_LPJ_G0030071
 protein coding gene Chr5:139917319-139918577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029970
 protein coding gene Chr5:153364907-153366165 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030639
 protein coding gene Chr5:137592302-137593560 (+)
PWK/PhJ MGP_PWKPhJ_G0028986
 protein coding gene Chr5:132451750-132453008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028821
 protein coding gene Chr5:135156744-135158002 (+)
WSB/EiJ MGP_WSBEiJ_G0029345
 protein coding gene Chr5:138343806-138345064 (+)



Homology
more
  • Human Ortholog
    CLDN3, claudin 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN3, claudin 3
  • Synonyms
    C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
  • Links
    NCBI Gene ID: 1365
    neXtProt AC: NX_O15551
    UniProt: O15551

  • Chr Location
    7q11.23; chr7:73768997-73770270 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are fertile with mutant males exhibiting normal spermatogenesis and fully functional Sertoli cell tight junctions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    112
  • cDNA Data
    18
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070473 Ensembl Gene Model | MGI Sequence Detail 1259 C57BL/6J ±  kb
    transcript ENSMUST00000094245 Ensembl | MGI Sequence Detail 1259 Not Applicable  
    polypeptide ENSMUSP00000091799 Ensembl | MGI Sequence Detail 219 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 4
      cDNA 18
      Primer pair 9
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140814
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 17
      Phenotypes 23
    • Earliest
      J:43620 Katahira J, et al., Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997 Oct 17;272(42):26652-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory